S1314
Monoclonal Anti-SERCa2 ATPase antibody produced in mouse
clone 2A7-A1, ascites fluid
Synonym(s):
Anti-ATP2B, Anti-DAR, Anti-DD, Anti-SERCA2
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100 μL
€704.00
€704.00
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100 μL
€704.00
About This Item
€704.00
Please contact Customer Service for Availability
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biological source
mouse
Quality Level
conjugate
unconjugated
antibody form
ascites fluid
antibody product type
primary antibodies
clone
2A7-A1, monoclonal
mol wt
antigen 110 kDa
contains
0.05% sodium azide
species reactivity
guinea pig, human, canine, mouse, rat, rabbit
technique(s)
immunoprecipitation (IP): suitable
western blot: suitable
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... ATP2A2(488)
mouse ... Atp2a2(11938)
rat ... Atp2a2(29693)
General description
SERCa2 ATPase (sarco/endoplasmic reticulum calcium-ATPase 2) is also known as ATP2A2 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2). It codes for SERCA2a and SERCA2b, that are expressed in all tissues. SERCA2a is highly expressed in heart. SERCa2 is located on human chromosome 12q24.1.
Immunogen
canine cardiac sarcoplasmic reticulum vesicles
Application
Anti-SERCa2 ATPase antibody has been used in western blotting and immunocytochemistry.
Biochem/physiol Actions
Mutation of SERCa2 ATPase (sarco/endoplasmic reticulum calcium-ATPase 2) or ATP2A2 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2) causes Dyskeratosis follicularis. SERCA2a plays a major role in controlling cardiomyocyte Ca2+. ATP2A2 mutation may cause Darier disease (DD).
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Product No.
Description
Pricing
Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Clinical case of acral hemorrhagic Darier's disease is not caused by mutations in exon 15 of the ATP2A2 gene
Pecina-Slaus N, et al.
Collegium Antropologicum, 27(1), 125-133 (2003)
Hypoxia-driven sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) downregulation depends on low-density lipoprotein receptor-related protein 1 (LRP1)-signalling in cardiomyocytes
Revuelta-Lopez E, et al.
Journal of Molecular and Cellular Cardiology, 85, 25-36 (2015)
Impaired cardiac performance in heterozygous mice with a null mutation in the sarco(endo)plasmic reticulum Ca2+-ATPase isoform 2 (SERCA2) gene
Periasamy M, et al.
The Journal of Biological Chemistry, 274(4), 2556-2562 (1999)
Ya-Ming Meng et al.
Oncoimmunology, 7(3), e1408745-e1408745 (2018-02-06)
We recently identified CXCR4 as a novel vascular marker for vessel sprouting in hepatocellular carcinoma (HCC) tissues. Thus, CXCR4+ endothelial cells (ECs) could serve as a potential predictor for patients who may benefit from sorafenib treatment; however, the mechanism that
Daisuke Shimura et al.
American journal of physiology. Heart and circulatory physiology, 310(1), H92-103 (2015-11-01)
Sarcolipin (SLN) is a small proteolipid and a regulator of sarco(endo)plasmic reticulum Ca(2+)-ATPase. In heart tissue, SLN is exclusively expressed in the atrium. Previously, we inserted Cre recombinase into the endogenous SLN locus by homologous recombination and succeeded in generating
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