P4484

Purvalanol A

≥98% (HPLC), powder

• Synonym(s): 2-(1R-Isopropyl-2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurine, NG-60
• Empirical Formula (Hill Notation): C₁₉H₂₅ClN₆O
• CAS Number: 212844-53-6
• Molecular Weight: 388.89
• MDL number: MFCD02179211
• UNSPSC Code: 12352200
• PubChem Substance ID: 24898543
• NACRES: NA.77

Properties

• Assay: ≥98% (HPLC)
• form: powder
• solubility: methylene chloride: 50 mg/mL
• shipped in: dry ice
• storage temp.: −20°C
• SMILES string: CC(C)[C@H](CO)Nc1nc(Nc2cccc(Cl)c2)c3ncn(C(C)C)c3n1
• InChI: 1S/C19H25ClN6O/c1-11(2)15(9-27)23-19-24-17(22-14-7-5-6-13(20)8-14)16-18(25-19)26(10-21-16)12(3)4/h5-8,10-12,15,27H,9H2,1-4H3,(H2,22,23,24,25)/t15-/m0/s1
• InChI key: PMXCMJLOPOFPBT-HNNXBMFYSA-N

Description

Biochem/physiol Actions

Purvalanol A is a potent, cell-permeable cyclin-dependent protein kinase (cdk) inhibitor.

Purvalanol A is found to inhibit ABCG2 (ATP-binding cassette G2) transporter in vitro.[1] It is also known to attenuate cellular Src kinase action and induce cell cycle arrest at the G2 to M phase transition.[2]

Features and Benefits

This compound is featured on the CDKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves