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P3761

Sigma-Aldrich

Pentobarbital sodium salt

Synonym(s):

5-Ethyl-5-(1-methylbutyl)-2,4,6-trioxohexahydropyrimidine, Nembutal

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About This Item

Empirical Formula (Hill Notation):
C11H17N2NaO3
CAS Number:
57-33-0
Molecular Weight:
248.25
EC Number:
200-323-9
MDL number:
MFCD00070198
UNSPSC Code:
41116107
PubChem Substance ID:
24898448
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form

powder

Quality Level

200

drug control

USDEA Schedule II; Home Office Schedule 3; psychotrope (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada

solubility

H2O: soluble
alcohol: soluble

SMILES string

[Na].CCCC(C)C1(CC)C(=O)NC(=O)NC1=O

InChI

1S/C11H18N2O3.Na.H/c1-4-6-7(3)11(5-2)8(14)12-10(16)13-9(11)15;;/h7H,4-6H2,1-3H3,(H2,12,13,14,15,16);;

InChI key

PGOYUXGHADTNIB-UHFFFAOYSA-N

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Application

Pentobarbital sodium salt has been used as an anesthetic in rats[1] and mice[2][3] prior to various in vitro studies.

Biochem/physiol Actions

Pentobarbital (PB) is a barbiturate and a ligand of the γ-aminobutyric acid subtype A (GABAA) receptor.[4] It is a sedative anesthetic[5] majorly used in rodent euthanasia.[4] Pentobarbital possesses hypnotic functionality[4] and muscle relaxing properties.[5] It enhances GABAergic activity.[6] Intraperitoneal injection of PB may result in loss of righting reflex (LORR) and heartbeat cessation.[5]

Pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

Signal Word

Danger

Hazard Statements

H301,H336,H361d

Hazard Classifications

Acute Tox. 3 Oral - Repr. 2 - STOT SE 3

Target Organs

Central nervous system

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
SLBG3215V
SLBF7349V
060M1523V
SLBC2478V
SLBB7285V

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Questions

1–5 of 5 Questions  

  1. Is Pentobarbital sodium salt available as a solution?

    1 answer

    1. We do not offer a solution of pentobarbital as it is not stable as a solution.

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  2. How can I store my solution of Pentobarbital sodium salt, Product P3761?

    1 answer

    1. Solutions of the sodium salt are typically pH 9.0 - 11.0 (BP/USP). If the pH is lowered, the free acid will precipitate from solution. Solutions decompose on standing, the decomposition being accelerated at higher temperatures.  We recommend to make solutions fresh.

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  3. What is the Department of Transportation shipping information for this product?

    1 answer

    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

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  4. How can I solubilize Pentobarbital sodium salt, Product P3761?

    1 answer

    1. This product is soluble in water (50 mg/ml), with heat and sonication as needed, yielding a clear to slightly hazy, colorless solution.

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  5. What is the shelf life for Pentobarbital sodium salt, Product P3761?

    1 answer

    1. Product No. P3761 has a retest date of 3 years from date of manufacture.

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