The solubility of this item is 1mg/ml as mentioned on the COA.
Link to sample COA: https://www.sigmaaldrich.com/certificates/sapfs/PROD/sap/certificate_pdfs/COFA/Q14/H7640-5MG0000336127.pdf
H7640
Heparan sulfate sodium salt from bovine kidney
Heparan sulfate sodium salt from bovine kidney
powder, extracellular matrix component
Synonym(s):
Heparitin sulfate sodium salt
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1 MG
€378.00
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€584.00
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€1,020.00
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1 MG
€378.00
5 MG
€584.00
10 MG
€1,020.00
About This Item
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Application
Biochem/physiol Actions
Constituent of membrane-associated proteoglycans suggested to contribute to cell-cell adhesion
Heparan sulphate (HS), a ubiquitous glycosaminoglycan, is a polymer of D-glucuronic acid or L-iduronic acid and D-glucosamine (GlcA) sugars.[4] It is synthesized in the cis-Golgi as heparan. In Golgi, final heparan sulphate is synthesized in by the action of enzymes N- and O-HS-sulphotransferases and HS epimerase. The mature HS has 50 to 200 disaccharide units.[5] It is part of the extracellular matrix (ECM) and plays a key role in the oncogenic pathway. Deregulation of heparin sulfate metabolism is implicated in cancer progression.[6] HS is associated with the onset of infectious diseases and inflammatory conditions.[7] HS interaction with Aβ fibrils contributes to the pathophysiology of Alzheimer′s disease.[8]Heparan sulphate is a constituent of membrane-associated proteoglycans suggested to contribute to cell-cell adhesion.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Pathophysiology of heparan sulphate: many diseases, few drugs
Lindahl Ulf and Kjellen L
Journal of Internal Medicine, 273(6), 555-571 (2013)
Molecular diversity of heparan sulfate
Esko JD and Lindahl Ulf
The Journal of Clinical Investigation, 108(2), 169-173 (2001)
K Fuxe et al.
Brain research, 746(1-2), 25-33 (1997-01-23)
In the present paper immunocytochemical analysis at the fluorescence microscopical level has been performed of neural cell adhesion. molecule (NCAM) immunoreactivity in the adult rat tel- and diencephalon in order to further substantiate the highly selective neuronal localization of NCAM
Fell-Muir lecture: heparan sulphate and the art of cell regulation: a polymer chain conducts the protein orchestra
Gallagher J
International Journal of Experimental Pathology, 96(4), 203-231 (2015)
Heparan sulfate and heparan sulfate proteoglycans in cancer initiation and progression
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Articles
Uncover more about glycosaminoglycans and proteoglycans including the structure of glycosaminoglycans (GAGs), the different types of GAGs, and their functions.
Glycosaminoglycans are large linear polysaccharides constructed of repeating disaccharide units.
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The molecular weight of this product is not determined. However, data from collective articles suggests the molecular weight could be around 14000 Da.
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