C5851
CGP 35348 hydrate
≥97% (NMR), solid
Synonym(s):
(3-Aminopropyl)(diethoxymethyl)phosphinic acid hydrate
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About This Item
Empirical Formula (Hill Notation):
C8H20NO4P · xH2O
CAS Number:
Molecular Weight:
225.22 (anhydrous basis)
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
Recommended Products
Assay
≥97% (NMR)
form
solid
storage condition
desiccated
color
white
solubility
H2O: >20 mg/mL
originator
Novartis
storage temp.
−20°C
SMILES string
O.CCOC(OCC)P(O)(=O)CCCN
InChI
1S/C8H20NO4P.H2O/c1-3-12-8(13-4-2)14(10,11)7-5-6-9;/h8H,3-7,9H2,1-2H3,(H,10,11);1H2
InChI key
SRBHGEXMDCJOMS-UHFFFAOYSA-N
Application
CGP 35348 hydrate has been used as a γ-aminobutyric acid-B (GABAB) receptor inhibitor:
- to study its effects on intrinsic optical signal (IOS) in rat hippocampus
- alone or in combination with sodium salicylate to study its effects on auditory responses in the rat′s dorsal cortex of rat
- to study its effects on hepatocellular carcinoma cells (HCC)
Biochem/physiol Actions
CGP 35348 is a γ-aminobutyric acid-B (GABAB) receptor antagonist. It has a higher affinity towards post-versus presynaptic receptors that can penetrate the blood-brain barrier.
Features and Benefits
This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the GABAB Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Caution
Product is hygroscopic
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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N G Bowery
Annual review of pharmacology and toxicology, 33, 109-147 (1993-01-01)
In conclusion, GABAB receptors appear to be of major importance in synaptic processing within the brain and are present at both post- and presynaptic sites. Their activation can hyperpolarize neurones and diminish neurotransmitter release from presynaptic terminals. We already know
Q Gillani et al.
BioMed research international, 2014, 295215-295215 (2014-05-08)
To study the effect of CGP 35348 on learning and memory in albino mice following hypoxia ischemia insult, 10 days old albino mice were subjected to right common carotid artery ligation followed by 8% hypoxia for 25 minutes. Following brain
Madhu P Sirivelu et al.
Brain research, 1248, 107-114 (2008-11-19)
Interleukin-1beta (IL-1beta), a cytokine that is closely associated with inflammation and immune stress, is known to interfere with reproductive functions. Earlier studies have demonstrated that IL-1beta inhibits the luteinizing hormone (LH) surge during the afternoon of proestrus in female rats.
Chirag R Patel et al.
Frontiers in neurology, 5, 235-235 (2014-12-03)
Sodium salicylate (SS) is a widely used medication with side effects on hearing. In order to understand these side effects, we recorded sound-driven local-field potentials in a neural structure, the dorsal cortex of the inferior colliculus (ICd). Using a microiontophoretic
Zhiyang Song et al.
Pain, 147(1-3), 241-248 (2009-10-20)
The aim of the present study was to examine the role of the spinal serotonergic system in the pain relieving effect of spinal cord stimulation (SCS) using a rat model of mononeuropathy. Tactile withdrawal thresholds, cold responses and heat withdrawal
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