C0166
Cys-Gly
≥85% (TLC), suitable fo HPLC
Synonym(s):
L-cysteinyl-glycine
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About This Item
Empirical Formula (Hill Notation):
C5H10N2O3S
CAS Number:
Molecular Weight:
178.21
MDL number:
UNSPSC Code:
12352209
PubChem Substance ID:
NACRES:
NA.26
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product name
Cys-Gly, ≥85% (TLC)
Assay
≥85% (TLC)
form
solid
technique(s)
HPLC: suitable
storage temp.
−20°C
SMILES string
NC(CS)C(=O)NCC(O)=O
InChI
1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)
InChI key
ZUKPVRWZDMRIEO-UHFFFAOYSA-N
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General description
Cys-Gly, a dipeptide is a catabolic byproduct of glutathione.
Application
Cys-Gly has been used for derivatization by p-hydroxymercury benzoate (PHMB) for calibration of reversed phase chromatography coupled on-line and sequentially with a UV−visible diode array detector (RPLC-DAD).
Biochem/physiol Actions
Cys-Gly is a precursor for glutathione biosynthesis in the neurons. It favors reactive oxygen species generation in the presence of transition metal ions. A normal level of cys-gly is essential for normal cellular function.
L-Cysteine-L-Glycine (Cys-Gly) is used in studies on the homeostasis of glutathione. Cys-Gly is an important molecule for study in the areas of thiol homeostasis, oxidative stress and metals management.
Other Notes
Glutathione fragment
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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Intracellular metabolism of 4-hydroxy-2-nonenal (HNE), a major product and mediator of oxidative stress and inflammation, is analyzed in resting and fMLP-stimulated human polymorphonuclear leukocytes (PMNL), where this compound is generated during activation of the respiratory burst. HNE consumption rate in
Synthesis of the antioxidant glutathione in neurons: supply by astrocytes of CysGly as precursor for neuronal glutathione
Dringen R, et al.
The Journal of Neuroscience, 19(2), 562-569 (1999)
Rafał Głowacki et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 877(28), 3400-3404 (2009-06-30)
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Journal of the American Society for Mass Spectrometry, 23(6), 1019-1023 (2012-03-01)
The radical cations of Cys-Gly and Gly-Cys were studied using ion-molecule reactions (IMR), infrared multiple-photon dissociation (IRMPD) spectroscopy, and density functional theory (DFT) calculations. Homolytic cleavage of the S-NO bond of nitrosylated precursors generated radical cations with the radical site
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