00541

Ruthenium Red

for microscopy, 85.0-115.0% (calc. on dry basis, AT)

• Synonym(s): Ammoniated ruthenium oxychloride
• Linear Formula: [(NH₃)₅RuORu(NH₃)₄ORu(NH₃)₅]Cl₆
• CAS Number: 11103-72-3
• Molecular Weight: 786.35
• Colour Index Number: 77800
• MDL number: MFCD00011479
• UNSPSC Code: 12171500
• PubChem Substance ID: 329747091
• NACRES: NA.47

Properties

• grade: for microscopy
• Quality Level: 100
• Assay: 85.0-115.0% (calc. on dry basis, AT)
• form: powder
• impurities: ~5% water
• solubility: water: 10 mg/mL, clear to turbid
• εmax: ≥150 at 529-539 nm
• application(s): diagnostic assay manufacturing; hematology; histology
• storage temp.: room temp
• SMILES string: N.N.N.N.N.N.N.N.N.N.N.N.N.N.[Cl-].[Cl-].[Cl-].[Cl-].[Cl-].[Cl-].[Ru++]O[Ru++]O[Ru++]; N.N.N.N.N.N.N.N.N.N.N.N.N.N.[Cl-].[Cl-].[Cl-].[Cl-].[Cl-].[Cl-].[Ru++]O[Ru++]O[Ru++]
• InChI: 1S/6ClH.14H3N.2O.3Ru/h6*1H;14*1H3;;;;;/q;;;;;;;;;;;;;;;;;;;;;;3*+2/p-6
• InChI key: ZXYSDUPLHOJIOR-UHFFFAOYSA-H

Description

General description

Ruthenium red is an inorganic cationic dye. It is also known as ammoniated ruthenium oxychloride. It is a large coordination complex consisting of three metal atoms connected by bridging oxygens, in addition to multiple amine ligands.

Application

Inhibits mitochondrial Ca²⁺ uniporter; capsaicin antagonist; blocks VR1 vanilloid receptor-coupled ion channels.

Ruthenium red is suitable for use in light microscopy to stain pectins. It is also used to stain glycosaminoglycans by employing a two-color staining method with alcian blue. It serves as a typical basic dye at a higher pH that stains nuclei, Nissl substance, cartilage matrix, and mast cell granules. Other applications involving light microscopy include staining resin-embedded material. Ruthenium red is an important component of fixatives of the bacterial glycocalyx.

Biochem/physiol Actions

Ruthenium red inhibits mitochondrial Ca2+ uniporter. It is a known capsaicin antagonist. Additionally, it is known to block VR1 vanilloid receptor-coupled ion channels.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H302
• Precautionary Statements: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class Code: 13 - Non Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable