(±)-Dropropizine is an antitussive therapeutic agent that inhibits cough through the peripheral mode of action.[1]
Application
(±)-Dropropizine may be used as a reference standard for the determination of (±)-dropropizine in pharmaceutical formulations by spectrophotometric method.[2]
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The mechanism of action of levodropropizine has been investigated in different models of experimentally-induced cough in guinea-pigs. In particular it has been demonstrated that the antitussive drug has a peripheral site of action by injecting the drug intracerebroventricularly (i.c.v.). In
British journal of pharmacology, 117(5), 853-858 (1996-03-01)
1. Levodropropizine (LVDP) is an effective antitussive drug. Its effects on single-unit discharge of vagal afferent C-fibres were tested in anaesthetized cats to assess whether an inhibition of vagal C-fibres is involved in its antitussive properties. Vagal C-fibres, identified by
Novel route for the resolution of both enantiomers of dropropizine by using oxime esters and supported lipases of Pseudomonas cepacia.
Salunkhe M M, et al.
Enzyme and Microbial Technology, 28(4-5), 333-338 (2001)
Cough in children is among the most common problems managed by pediatricians, and occurs more frequently in preschool than in older children. Most acute episodes of cough are due to viral upper respiratory tract infections. The morbidity associated with acute
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