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Tetramethylrhodamine methyl ester perchlorate

Name: Tetramethylrhodamine methyl ester perchlorate
Brand: SIAL

for fluorescence, ≥95% (HPCE)

Synonym(s):

TMRM

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About This Item

Linear Formula:

C₂₅H₂₅N₂O₃ · ClO₄

CAS Number:

115532-50-8

Molecular Weight:

500.93

Beilstein:

7162165

MDL number:

MFCD00274460

UNSPSC Code:

12171500

PubChem Substance ID:

24889004

grade

for fluorescence

Assay

≥95% (HPCE)

solubility

DMSO: soluble
alcohols: soluble

fluorescence

λ_ex 540 nm; λ_em 595 nm in DMSO

storage temp.

2-8°C

SMILES string

[O-]Cl(=O)(=O)=O.COC(=O)c1ccccc1C2=C3C=C\C(C=C3Oc4cc(ccc24)N(C)C)=[N+](\C)C

InChI

1S/C25H25N2O3.ClHO4/c1-26(2)16-10-12-20-22(14-16)30-23-15-17(27(3)4)11-13-21(23)24(20)18-8-6-7-9-19(18)25(28)29-5;2-1(3,4)5/h6-15H,1-5H3;(H,2,3,4,5)/q+1;/p-1

InChI key

PFYWPQMAWCYNGW-UHFFFAOYSA-M

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Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Other Notes

Potential-sensitive probe for measuring membrane potential changes in mitochondria

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Simultaneous imaging of cell and mitochondrial membrane potentials.

D L Farkas et al.

Biophysical journal, 56(6), 1053-1069 (1989-12-01)

The distribution of charged membrane-permeable molecular probes between intracellular organelles, the cytoplasm, and the outside medium is governed by the relative membrane electrical potentials of these regions through coupled equilibria described by the Nernst equation. A series of highly fluorescent

Glucose Homeostasis Is Important for Immune Cell Viability during Candida Challenge and Host Survival of Systemic Fungal Infection.

Timothy M Tucey et al.

Cell metabolism, 27(5), 988-1006 (2018-05-03)

To fight infections, macrophages undergo a metabolic shift whereby increased glycolysis fuels antimicrobial inflammation and killing of pathogens. Here we demonstrate that the pathogen Candida albicans turns this metabolic reprogramming into an Achilles' heel for macrophages. During Candida-macrophage interactions intertwined

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