Protocadherin-19, also known as Potential calcium-dependent cell-adhesion protein (PCDH19), is a single-pass type I membrane protein that is moderately expressed in all regions of the brain and ovary, and has low expression in other tissues. Defects in PCDH19 cause epileptic encephalopathy, early infantile type 9 (EIEE9), also known as epilepsy female-restricted with mental retardation.
Immunogen
Epitope: Cytoplasmic domain
KLH-conjugated linear peptide corresponding to the cytoplasmic domain of human Protocadherin 19.
Application
Detect Protocadherin 19 using this Anti-Protocadherin 19 Antibody validated for use in IHC (Paraffin).
Immunohistochemistry Analysis: A 1:500 dilution from a representative lot detected Protocadherin 19 in mouse hypothalamus and hind brain tissues, whereas a 1:2,000 dilution from a representative lot detected Protocadherin 19 in human cerebellum tissue.
Research Category Cell Structure
Research Sub Category Adhesion (CAMs)
Quality
Evaluated by Immunohistochemistry in human cerebral cortex tissue.
Immunohistochemistry Analysis: A 1:500 dilution of this antibody detected Protocadherin 19 in human cerebral cortex tissue.
Target description
126 kDa calculated
Physical form
Affinity purified
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Storage and Stability
Stable for 1 year at 2-8°C from date of receipt.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Cerebral cortex expansion is a hallmark of mammalian brain evolution; yet, how increased neurogenesis is coordinated with structural and functional development remains largely unclear. The T-box protein TBR2/EOMES is preferentially enriched in intermediate progenitors and supports cortical neurogenesis expansion. Here
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