8.51054

CDI

1,1′-Carbonyldiimidazole Novabiochem^®

• Synonym(s): CDI, 1,1′-Carbonyl-diimidazole
• Empirical Formula (Hill Notation): C₇H₆N₄O
• CAS Number: 530-62-1
• Molecular Weight: 162.15
• MDL number: MFCD00005286
• UNSPSC Code: 12352005
• EC Index Number: 208-488-9
• NACRES: NA.22

Properties

• Quality Level: 200
• product line: Novabiochem^®
• Assay: ≥97.0% (GC)
• form: powder
• potency: 1071 mg/kg LD₅₀, oral (Rat)
• reaction suitability: reaction type: Coupling Reactions
• manufacturer/tradename: Novabiochem^®
• pH: 7.7 (20 °C, 50 g/L in H₂O)
• mp: 116-120 °C
• application(s): peptide synthesis
• storage temp.: 2-8°C
• InChI: 1S/C7H6N4O/c12-7(10-3-1-8-5-10)11-4-2-9-6-11/h1-6H
• InChI key: PFKFTWBEEFSNDU-UHFFFAOYSA-N

Description

General description

A useful coupling reagent for amidations, esterifications and thioesterifications ^[1,2,3,4].

Literature references

^[1] H. A. Staab (1957) Ann. Chem., 609, 75.
^[2] R. Paul, et al. (1960) J. Am. Chem. Soc., 82, 4596.
^[3] R. Paul, et al. (1962) J. Org. Chem., 27, 2094.
^[4] T. Kamijo, et al. (1984) Chem. Pharm. Bull., 32, 5044.

Linkage

Replaces: 01-62-0002

Analysis Note

Assay (GC, area%): ≥ 97.0 % (a/a)
Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Solubility (0.6 mmole ind 2 ml DMF): clearly soluable

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Pictograms: GHS05,GHS07
• Signal Word: Danger
• Hazard Statements: H302 - H314
• Precautionary Statements: P260 - P270 - P280 - P301 + P312 - P303 + P361 + P353 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Eye Dam. 1 - Skin Corr. 1B
• Storage Class Code: 8A - Combustible, corrosive hazardous materials
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable