523350

PTIO

Nitric oxide radical scavenger.

• Synonym(s): PTIO, 2-Phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide
• Empirical Formula (Hill Notation): C₁₃H₁₇N₂O₂
• CAS Number: 18390-00-6
• Molecular Weight: 233.29
• MDL number: MFCD00059929
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (titration)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• color: dark blue
• solubility: ethanol: soluble; water: soluble
• shipped in: ambient
• storage temp.: −20°C
• InChI: 1S/C13H17N2O2/c1-12(2)13(3,4)15(17)11(14(12)16)10-8-6-5-7-9-10/h5-9H,1-4H3
• InChI key: DYUUGILMVYJEHY-UHFFFAOYSA-N

Description

General description

Nitric oxide radical scavenger. Reacts with nitric oxide in a stoichiometric manner without affecting nitric oxide synthase activity. Inhibits the enhanced vascular permeability in solid tumors.

Nitric oxide radical scavenger. Reacts with nitric oxide in a stoichiometric manner, without affecting nitric oxide synthase activity. Inhibits enhanced vascular permeability in solid tumors.

Biochem/physiol Actions

Cell permeable: no

Primary Target
Nitric oxide radical scavenger

Product does not compete with ATP.

Reversible: no

Warning

Toxicity: Irritant (B)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Avoid freeze/thaw cycles of solutions.

Other Notes

Hogg, N., et al. 1995. Free Radic. Res. 22, 47.
Maeda, H., et al. 1994. Jpn. J. Cancer Res.85, 331.
Yoshida, M., et al. 1994. Biochem. Biophys. Res. Commun.202, 923.
Akaike, T., et al. 1993. Biochemistry32, 827.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable