189405-M

Aurora Kinase Inhibitor III

The Aurora Kinase Inhibitor III, also referenced under CAS 879127-16-9, controls the biological activity of Aurora Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• Synonym(s): Aurora Kinase Inhibitor III, Cyclopropanecarboxylic acid-(3-(4-(3-trifluoromethyl-phenylamino)-pyrimidin-2-ylamino)-phenyl)-amide, Aurora Kinase Inhibitor III
• Empirical Formula (Hill Notation): C₂₁H₁₈F₃N₅O
• CAS Number: 879127-16-9
• Molecular Weight: 413.40
• MDL number: MFCD09265250
• UNSPSC Code: 12352200

Properties

• Assay: ≥95% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: white
• solubility: ethanol: 20 mg/mL; DMSO: 50 mg/mL
• storage temp.: 2-8°C
• InChI: 1S/C21H18F3N5O/c22-21(23,24)14-3-1-4-15(11-14)26-18-9-10-25-20(29-18)28-17-6-2-5-16(12-17)27-19(30)13-7-8-13/h1-6,9-13H,7-8H2,(H,27,30)(H2,25,26,28,29)
• InChI key: RDTDWGQDFJPTPD-UHFFFAOYSA-N

Description

General description

A cell-permeable 2,4-dianilinopyrimidine compound that acts as an ATP-competitive, potent, but non-selective inhibitor of Aurora A (IC₅₀ = 42 nM). At higher concentrations, also inhibits the activities of other kinases, such as Lck, Bmx, IGF-1R, and Syk (IC₅₀ = 131, 386, 591, and 887 nM, respectively).

Biochem/physiol Actions

Primary Target
Aurora Kinase A

Target IC₅₀: 42 nM against Aurora A; 131, 386, 591, and 887 nM, against Lck, Bmx, IGF-1R, and Syk , respectively

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Zhang, Q., et al. 2006. J. Am. Chem. Soc.128, 2182.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable