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850482C

Avanti

16:0-18:0 (11-12BR) PC

Name: 16:0-18:0 (11-12BR) PC
Brand: AVANTI

1-palmitoyl-2-(11,12-dibromo)stearoyl-sn-glycero-3-phosphocholine, chloroform

Synonym(s):

1-hexadecanoyl-2-(11,12-dibromooctadecanoyl)-sn-glycero-3-phosphocholine

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About This Item

Empirical Formula (Hill Notation):

C₄₂H₈₂NO₈PBr₂

CAS Number:

324054-54-8

Molecular Weight:

919.88

UNSPSC Code:

12352211

NACRES:

NA.25

Assay

>99% (TLC)

form

liquid

packaging

pkg of 1 × 1 mL (850482C-10mg)

manufacturer/tradename

Avanti Research^™ - A Croda Brand 850482C

concentration

10 mg/mL (850482C-10mg)

shipped in

dry ice

storage temp.

−20°C

General description

16:0-18:0 (11-12BR) PC (1-palmitoyl-2-(11,12-dibromo) stearoyl-sn-glycero-3-phosphocholine) consists of brominated stearoyl chains. This brominated-PC lipid is non-hygroscopic and has a stability of 1 year.

Application

16:0-18:0 (11-12BR) PC (1-palmitoyl-2-(11,12-dibromo) stearoyl-sn-glycero-3-phosphocholine) may be used:

in phospholipid vesicle preparation for tryptophan (Trp) penetration depth experiments
to determine the bromination effect at different positions along the fatty acid chains
for quenching of human heat shock protein 70 (Hsp70) tryptophan (Trp) fluorescence

Biochem/physiol Actions

16:0-18:0 (11-12BR) PC (1-palmitoyl-2-(11,12-dibromo) stearoyl-sn-glycero-3-phosphocholine) can be used in the preparation of vesicles.

Packaging

5 mL Clear Glass Sealed Ampule (850482C-10mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Pictograms

GHS06,GHS08

Signal Word

Danger

Hazard Statements

H302,H315,H319,H331,H336,H351,H361d,H372

Precautionary Statements

P201 - P260 - P264 - P280 - P304 + P340 + P311 - P403 + P233

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

Target Organs

Central nervous system

WGK

WGK 3

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Human heat shock protein 70 (Hsp70) as a peripheral membrane protein.

Ajay K Mahalka et al.

Biochimica et biophysica acta, 1838(5), 1344-1361 (2014-02-01)

While a significant fraction of heat shock protein 70 (Hsp70) is membrane associated in lysosomes, mitochondria, and the outer surface of cancer cells, the mechanisms of interaction have remained elusive, with no conclusive demonstration of a protein receptor. Hsp70 contains

Interaction of the Mechanosensitive Channel, MscS, with the Membrane Bilayer through Lipid Intercalation into Grooves and Pockets.

Tim Rasmussen et al.

Journal of molecular biology, 431(17), 3339-3352 (2019-06-08)

All membrane proteins have dynamic and intimate relationships with the lipids of the bilayer that may determine their activity. Mechanosensitive channels sense tension through their interaction with the lipids of the membrane. We have proposed a mechanism for the bacterial

Tryptophan probes reveal residue-specific phospholipid interactions of apolipoprotein C-III.

Candace M Pfefferkorn et al.

Biochimica et biophysica acta, 1848(11 Pt A), 2821-2828 (2015-08-25)

Apolipoproteins are essential human proteins for lipid metabolism. Together with phospholipids, they constitute lipoproteins, nm to μm sized particles responsible for transporting cholesterol and triglycerides throughout the body. To investigate specific protein-lipid interactions, we produced and characterized three single-Trp containing

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