TissueFab® - Bone support bioink is suitable for printing bone scaffold or using as a supporting bioink for bone specific hydrogel/matrix bioink. It is formulated with optimal ratio of PCL and HAp, which shows excellent printability and osteogenic bioactivity. Polycaprolactone (PCL) is a synthetic biodegradable polymer that has been widely used as 3D printed bone scaffold material. Hydroxyapatite (HAp) has a chemical similarity with the mineralized phase of bone which accounts for their excellent biocompatibility and osteoinductive and osteoconductive properties favorable for bone regeneration.
Packaging
5g in glass bottle
Legal Information
TISSUEFAB is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
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Synthetic polymeric scaffolds are commonly used in bone tissue engineering (BTE) due to their biocompatibility and adequate mechanical properties. However, their hydrophobicity and the lack of specific cell recognition sites confined their practical application. In this study, to improve the
Bioprocess and biosystems engineering, 34(4), 505-513 (2010-12-21)
For tissue engineering and regeneration, a porous scaffold with interconnected networks is needed to guide cell attachment and growth/ingrowth in three-dimensional (3D) structure. Using a rapid prototyping (RP) technique, we designed and fabricated 3D plotting system and three types of
Journal of biomedical materials research. Part B, Applied biomaterials, 107(4), 1254-1263 (2018-10-10)
Defect-specific bone regeneration using 3-dimensional (3D) printing of block bone has been developed. Polycaprolactone (PCL) is biocompatible polymer that can be used as 3D scaffold. The aim of this study is to assess the biocompatibility and osteogenic efficacy of 3D
Journal of biomedical materials research. Part A, 94(1), 241-251 (2010-02-19)
Polycaprolactone (PCL) is a synthetic biodegradable polymer that has been approved for use as bone graft substitutes. In this study, PCL scaffolds incorporating hydroxyapatite (HAp) particles were fabricated by combined solvent casting and particulate leaching techniques. The average pore dimension
Reconstruction of complex, craniofacial bone defects often requires autogenous vascularized bone grafts, and still remains a challenge today. In order to address this issue, we isolated the stromal vascular fraction (SVF) from adipose tissues and maintained the phenotypes and the
Learn how 3D bioprinting is revolutionizing drug discovery with highly-controllable cell co-culture, printable biomaterials, and its potential to simulate tissues and organs. This review paper also compares 3D bioprinting to other advanced biomimetic techniques such as organoids and organ chips.
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