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363502

Sigma-Aldrich

Poly[(R)-3-hydroxybutyric acid]

natural origin

Synonym(s):

(R)-3-Hydroxybutyric acid polymerized, PHB

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100 G
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10 G
€166.00
100 G
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About This Item

Linear Formula:
[COCH2CH(CH3)O]n
CAS Number:
29435-48-1
MDL number:
MFCD00134263
UNSPSC Code:
12162002
PubChem Substance ID:
24862200
NACRES:
NA.23

€166.00

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Quality Level

200

transition temp

Tm 172 °C (DSC)

SMILES string

CC(O)CC(O)=O

InChI

1S/C12H20O6/c1-8(14)6-11(15)18-10(3)7-12(16)17-9(2)4-5-13/h5,8-10,14H,4,6-7H2,1-3H3

InChI key

QLACRIKFZRFWRU-UHFFFAOYSA-N

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General description

Biocompatible, biodegradable polymer.

Application

Poly[(R)-3-hydroxybutyric acid (PHB) is a biodegradable and biocompatible polymer produced by several bacterial species, owing to its low resorbability and tunable properties, it may find uses in a variety of applications such as tissue engineering, controlled release systems etc.[1][2][3]

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
BCCL6399
BCCK0884
BCCK0256
BCCH3975
BCCD6713

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Molecular mass of poly [(R)-3-hydroxybutyric acid] produced in a recombinant Escherichia coli.
Kusaka S, et al.
Applied Microbiology and Biotechnology, 47(2), 140-143 (1997)
Proliferation and skeletal myotube formation capability of C2C12 and H9c2 cells on isotropic and anisotropic electrospun nanofibrous PHB scaffolds.
Ricotti L, et al.
Biomedical Materials (Bristol, England), 7(3), 035010-035010 (2012)
Engineering of Saccharomyces cerevisiae for the production of poly-3-d-hydroxybutyrate from xylose.
Sandstrom A G, et al.
AMB Express, 5(1), 14-14 (2015)
Andreas Wahl et al.
BMC microbiology, 12, 262-262 (2012-11-20)
Poly(3-hydroxybutyrate) (PHB) granules are important storage compounds of carbon and energy in many prokaryotes which allow survival of the cells in the absence of suitable carbon sources. Formation and subcellular localization of PHB granules was previously assumed to occur randomly
Rui-Yan Wang et al.
PloS one, 8(3), e57943-e57943 (2013-03-14)
A couple of DNA ligation-independent cloning (LIC) methods have been reported to meet various requirements in metabolic engineering and synthetic biology. The principle of LIC is the assembly of multiple overlapping DNA fragments by single-stranded (ss) DNA overlaps annealing. Here
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Questions

1–7 of 7 Questions  

  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  3. What is the organism from which PHB is extracted?

    1 answer

    1. This product is manufactured by fermentation of cell culture. The exact organism is considered proprietary.

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  4. Do you know what the solubility of PHB in chloroform is?

    1 answer

    1. The solubility of this product in chloroform has not been tested. However, historical data suggests that 5 parts PHB powder can be mixed with 95 parts chloroform in an explosion-proof pressure tube, sealed, and heated for a few minutes at 90°C.

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  5. We are using PHB and a standard for our HPLC method. This involves conversion to crotonic acid in boiling sulfuric acid. However, once cooled, crystals are formed. Any advice in how to deal with this?

    1 answer

    1. Both PHB and crotonic acid are prone to crystallization from aqueous solutions. It is likely that the concentration of one or more of these solutes exceeds the saturation point in the solvent being used.

      Using a lower concentration of PHB (either less PHB or more solvent) may inhibit the formation of crystals. Crystals recovered from the solution by filtration can be resolubilized using water, and this process can be expedited using sonication.

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  6. What is the molecular weight of this polymer?

    1 answer

    1. The molecular weight of this material is not tested on a lot-to-lot basis. However, historical information suggests a molecular weight of approximately 400-500 kDa.

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  7. Do you have data about the purity of this sample of PHB?

    1 answer

    1. Unfortunately, this product is not tested for purity.

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