SAB5300461

Monoclonal Anti-FOXP3 antibody produced in mouse

clone 2A11G9, ascites fluid

• Synonym(s): AIID, IPEX, JM2, PIDX, XPID
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: mouse
• conjugate: unconjugated
• antibody form: ascites fluid
• antibody product type: primary antibodies
• clone: 2A11G9, monoclonal
• species reactivity: mouse, human
• technique(s): direct ELISA: 1:10,000; immunohistochemistry: 1:200-1:1,000; indirect immunofluorescence: 1:200-1:1,000; western blot: 1:500-1:2,000
• isotype: IgG1
• NCBI accession no.: NM_014009
• UniProt accession no.: Q9BZS1
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... Foxp3(50943)

Description

General description

Forkhead box P3 (FOXP3) is located on human chromosome Xp11.23-Xq13.3. FOXP3 is a putative DNA-binding protein and is a member of the forkhead family. The protein is mainly expressed in the CD4⁺CD25⁺ regulatory T-cell subsets.

Immunogen

Purified recombinant fragment of human Foxp3 expressed in E.coli.
Mouse monoclonal antibody raised against Foxp3

Application

Monoclonal Anti-FOXP3 antibody has been used in immunohistochemistry (IHC).

Biochem/physiol Actions

Forkhead box P3 (FOXP3) plays an essential role in the development of CD4⁺CD25⁺ regulatory T cells and regulates immune homeostasis. It also acts as a transcriptional repressor. Polyadenylation signal mutation of the gene leads to immune dysregulation, polyendocrinopathy, enteropathy and X-linked inheritance (IPEX). Abnormalities in the gene expression are also associated with the pathogenesis of autism spectrum disorders (ASD) and unexplained recurrent spontaneous abortion (URSA).

Physical form

Ascitic fluid containing 0.03% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable