SAB4504126

Anti-phospho-Caspase 3 (pSer¹⁵⁰) antibody produced in rabbit

affinity isolated antibody

• Synonym(s): Anti-CASP-3, Anti-Caspase-3
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen 31 kDa
• species reactivity: mouse, rat, human
• concentration: ~1 mg/mL
• technique(s): ELISA: 1:40000; immunohistochemistry: 1:50-1:100; western blot: 1:500-1:1000
• NCBI accession no.: P42574
• UniProt accession no.: P42574
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: phosphorylation (pSer150)
• Gene Information: human ... CASP3(836)

Description

General description

Caspase-3 (CASP3) belongs to the class of cysteine proteases. CASP3 is an executioner caspase, which is cleaved and activated with the help of caspase-8 and caspase-9 initiator caspases. CASP3 is mapped to human chromosome 4q35.1.

Immunogen

The antiserum was produced against synthesized peptide derived from human Caspase 3 around the phosphorylation site of Ser150.

Immunogen Range: 116-165

Biochem/physiol Actions

Caspase-3 (CASP3) can degenerate multiple cellular proteins and results in morphological changes and DNA fragmentation in cells at the time of apoptosis. It participates in the growth stimulation. CASP3 plays a major role in the execution phase of apoptosis.

Features and Benefits

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Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable