C0551
Monoclonal Anti-CD11b antibody produced in mouse
clone ICRF44, purified immunoglobulin, buffered aqueous solution
Synonym(s):
Monoclonal Anti-CD11b
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
Recommended Products
biological source
mouse
Quality Level
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
ICRF44, monoclonal
form
buffered aqueous solution
mol wt
antigen 165-170 kDa
species reactivity
human
technique(s)
flow cytometry: 5 μL using 1 × 106 cells
isotype
IgG1
UniProt accession no.
shipped in
wet ice
storage temp.
2-8°C
target post-translational modification
unmodified
Gene Information
human ... ITGAM(3684)
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General description
CD11b is also known as Mac-1, CR3, MO-1 and C3bi receptor. It belongs to β 2 integrin family. The gene encodes the integrin α M chain. It is expressed on the surface of circulating monocytes, granulocytes, neutrophils, macrophages, dendritic cells and certain NK cells. It is present in subcellular granules in granulocytes and on subsets of macrophages.
Monoclonal anti-Human CD11b antibody (mouse IgG1 isotype) is derived from the hybridoma produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with human monocytes.
Specificity
Recognizes the CD11b α-chain of the human CD11b/CD18 complex. The antibody is useful for studies on cell adhesion and migration and for the detection of leukocyte adhesion deficiencies. It may be used to stain acetone-fixed cryostat sections or cell preparations. The epitope recognized by the antibody is formalin sensitive.
2nd Workshop: code no. M104
3rd Workshop: code no. 202 and 238
4th Workshop: code no. M47
2nd Workshop: code no. M104
3rd Workshop: code no. 202 and 238
4th Workshop: code no. M47
Immunogen
human monocytes.
Application
Monoclonal Anti-CD11b antibody produced in mouse has been used in immunostaining and flow cytometry.
Biochem/physiol Actions
CD11b/CD18 acts as a receptor for C3bi, clotting factor X, fibrinogen and ICAM-1. It is involved in cell-cell and cell-substrate interactions. It plays a crucial role in several immunological processes as well including leukocyte extravasation and phagocytosis. It also plays an important role in certain coagulation protease cascade and in cell migration.
Target description
CD11b α-chain of the human CD11b/CD18 complex is an α/β heterodimeric glycoprotein which belongs to the β2 integrin family. It is also known as Mac-1, CR3, MO-1 and C3bi receptor. CD11b is expressed on the surface of circulating monocytes, granulocytes and certain NK cells and is also present in subsets of macrophages. It functions as a receptor for iC3b, clotting factor X, fibrinogen and ICAM-1.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Liliane Fossati-Jimack et al.
PloS one, 8(2), e57082-e57082 (2013-03-02)
The CD11b/CD18 integrin (complement receptor 3, CR3) is a surface receptor on monocytes, neutrophils, macrophages and dendritic cells that plays a crucial role in several immunological processes including leukocyte extravasation and phagocytosis. The minor allele of a non-synonymous CR3 polymorphism
George Hajishengallis et al.
Clinical and diagnostic laboratory immunology, 9(2), 403-411 (2002-03-05)
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Zhang X, et al.
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HMGB1 promotes differentiation syndrome by inducing hyperinflammation via MEK/ERK signaling in acute promyelocytic leukemia cells
Tang L, et al,
Oncotarget, 8(16), 27314-27314 (2017)
S D Wright et al.
Proceedings of the National Academy of Sciences of the United States of America, 85(20), 7734-7738 (1988-10-01)
Human polymorphonuclear leukocytes (PMN) have previously been shown to bind to aggregates of fibrin and to fibrinogen-coated surfaces. During their interactions with fibrinogen-coated surfaces, PMN make such close contact with the surface that a portion of the secreted elastase activity
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