B1401

Bradykinin Fragment 1-5

≥97% (HPLC)

• Empirical Formula (Hill Notation): C₂₇H₄₀N₈O₆
• CAS Number: 23815-89-6
• Molecular Weight: 572.66
• MDL number: MFCD00076260
• UNSPSC Code: 12352200
• PubChem Substance ID: 24891591
• NACRES: NA.32

Properties

• Quality Level: 200
• Assay: ≥97% (HPLC)
• form: powder
• UniProt accession no.: P01042
• storage temp.: −20°C
• SMILES string: NC(CCCNC(N)=N)C(=O)N1CCCC1C(=O)N2CCCC2C(=O)NCC(=O)NC(Cc3ccccc3)C(O)=O
• InChI: 1S/C27H40N8O6/c28-18(9-4-12-31-27(29)30)24(38)35-14-6-11-21(35)25(39)34-13-5-10-20(34)23(37)32-16-22(36)33-19(26(40)41)15-17-7-2-1-3-8-17/h1-3,7-8,18-21H,4-6,9-16,28H2,(H,32,37)(H,33,36)(H,40,41)(H4,29,30,31)
• InChI key: USSUMSBPLJWFSZ-UHFFFAOYSA-N
• Gene Information: human ... KNG1 (includes EG:3827)

Description

Amino Acid Sequence

Arg-Pro-Pro-Gly-Phe

Biochem/physiol Actions

The bradykinin (BK) fragment (1-5) (RPPGF) is among the most stable of naturally occurring metabolites. It may be used as a marker for BK production in vivo. It is known that an intact Arg residue in the C-terminus is required for biological activities. BK 1-5 is the minimal peptide that inhibited α-thrombin-induced platelet aggregation and secretion and calcium mobilization. It also prevented α-thrombin from cleaving the thrombin receptor peptide, NATLDPRSFLLR, between arginine and serine. Such antithrombin activities of BK 1-5 may contribute to the cardioprotective nature of kinins.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves