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05-855R

Sigma-Aldrich

Anti-GluR1 Antibody, Recombinant, rabbit monoclonal

Upstate®, from rabbit

Synonym(s):

Anti-GluA1, Anti-GluR-1, Anti-GluR-A, Anti-GluR-K1, Anti-GluR1

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

purified antibody

antibody product type

primary antibodies

clone

monoclonal

species reactivity

rat, mouse

manufacturer/tradename

Upstate®

technique(s)

immunohistochemistry: suitable
western blot: suitable

NCBI accession no.

NP_000818.2

UniProt accession no.

P42261

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

mouse ... Gria1(14799)
rat ... Gria1(50592)

Specificity

Cat. # 05-855R recognizes the monomer and dimer of GluR1.
Reactivity with other species has not been determined.

Application

Anti-GluR1 Antibody, Recombinant is an antibody against GluR1 for use in WB, IH.
Immunohistochemistry: Cat. # 05-855R can detect GluR1 in rat brain tissue at 1:250 dilution.
Research Category
Neuroscience
Research Sub Category
Neurotransmitters & Receptors

Quality

Routinely evaluated by western blot on rat brain microsomal lysate.

Target description

Monomer at 106 kDa and Dimer at 200 kDa

Physical form

Format: Purified
Purified Antibody in 0.01M Tris-Glycine, 0.15M NaCl, pH 7.4, 0.05% NaN3with 40% glycerol.

Storage and Stability

Maintain at 2-8°C in undiluted aliquots for up to 1 year after date of receipt.

Analysis Note

Control
Rat brain microsomal lysate

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Description
Pricing

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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GluA1 in central amygdala increases pain but inhibits opioid withdrawal-induced aversion.
You-Qing Cai et al.
Molecular pain, 16, 1744806920911543-1744806920911543 (2020-03-13)
Rachel Thomas et al.
The Journal of biological chemistry, 298(8), 102245-102245 (2022-07-15)
Cortical glutamate and midbrain dopamine neurotransmission converge to mediate striatum-dependent behaviors, while maladaptations in striatal circuitry contribute to mental disorders. However, the crosstalk between glutamate and dopamine signaling has not been entirely elucidated. Here we uncover a molecular mechanism by
AMPA and GABA(A/B) receptor subunit expression in the cortex of adult squirrel monkeys during peripheral nerve regeneration.
Mowery, TM; Walls, SM; Garraghty, PE
Brain Research null
Central amygdala GluA1 facilitates associative learning of opioid reward.
Cai, YQ; Wang, W; Hou, YY; Zhang, Z; Xie, J; Pan, ZZ
The Journal of Neuroscience null
Gajanan P Shelkar et al.
The international journal of neuropsychopharmacology, 24(11), 907-919 (2021-08-08)
Enhancement of N-methyl-D-aspartate (NMDA) receptor function using glycine-site agonist D-cycloserine is known to facilitate fear extinction, providing a means to augment cognitive behavioral therapy in anxiety disorders. A novel class of glycine-site agonists has recently been identified, and we have
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