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A0424

Sigma-Aldrich

Alverine citrate salt

Synonym(s):

N-Ethyl-3,3′-diphenyldipropylamine, NSC 35459

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About This Item

Empirical Formula (Hill Notation):
C20H27N · C6H8O7
CAS Number:
5560-59-8
Molecular Weight:
473.56
EC Number:
226-929-3
MDL number:
MFCD00035086
UNSPSC Code:
12352100
PubChem Substance ID:
57653816
NACRES:
NA.22

form

powder

SMILES string

OC(=O)CC(O)(CC(O)=O)C(O)=O.CCN(CCCc1ccccc1)CCCc2ccccc2

InChI

1S/C20H27N.C6H8O7/c1-2-21(17-9-15-19-11-5-3-6-12-19)18-10-16-20-13-7-4-8-14-20;7-3(8)1-6(13,5(11)12)2-4(9)10/h3-8,11-14H,2,9-10,15-18H2,1H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)

InChI key

RYHCACJBKCOBTJ-UHFFFAOYSA-N

Gene Information

human ... HNF4A(3172) , HTR1A(3350)

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Application

Used for studies of pharmacological activity including:
  • Synergism with fluconazole against Saccharomyces cerevisiae and Candida albicans
  • Efficacy of combination with simeticone on abdominal pain associated with irritable bowel syndrome
  • Nutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis
  • Drug effects viewed from a signal transduction network perspective
  • Enhanced cytotoxic effect of proteasome inhibitor MG132
  • Mechanism of action on phasic smooth muscles

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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A general practice study to compare alverine citrate with mebeverine hydrochloride in the treatment of irritable bowel syndrome.
G J Tudor
The British journal of clinical practice, 40(7), 276-278 (1986-07-01)
M Bouvier et al.
Gastroenterologie clinique et biologique, 16(4), 334-338 (1992-01-01)
To analyse the mechanisms of the antispasmodic action of alverine, the effects of this drug on the spontaneous motility and nervous control of the proximal colon of the rabbit were studied in vivo. The electrical activity of the colonic smooth
Chinmoy Ghosh et al.
Drug testing and analysis, 2(6), 284-291 (2010-06-22)
A rapid and highly sensitive method for the determination of alverine (ALV) and its metabolite, para hydroxy alverine (PHA), in human plasma using LC-MS/MS in positive ion electrospray ionization (ESI) in multiple reactions monitoring (MRM) mode was developed and validated.
Engin Altintaş et al.
The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, 19(3), 174-179 (2008-12-31)
Successful colonoscopy depends on the insertion of the instrument to the cecum, a detailed examination, and minimal discomfort to the patient during the procedure. The aim of this study was to determine the effects of alverine citrate plus simethicone on
D Malka et al.
Journal of hepatology, 27(2), 399-403 (1997-08-01)
We report the case of a 67-year-old woman in whom onset and regression of acute hepatitis were closely related to the time of administration and withdrawal of the smooth muscle relaxant alverine. Antinuclear antibodies were positive, and their titer followed
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