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39205

Sigma-Aldrich

Dimethylaminomethyl-polystyrene

200-400 mesh particle size, extent of labeling: 3-4 mmol/g base loading, matrix crosslinked with 2% DVB

Synonym(s):

Benzyldimethylamine polymer-bound, Copolymer of styrene and divinylbenzene, dimethylaminomethylated, Polystyrene crosslinked with divinylbenzene, dimethylaminomethylated

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About This Item

Linear Formula:
CH2N(CH3)2 - [CH2CH(C6H55)]n
MDL number:
MFCD00144140
UNSPSC Code:
12352209
NACRES:
NA.22

reaction suitability

reaction type: solution phase peptide synthesis
reactivity: proton reactive

extent of labeling

3-4 mmol/g base loading

impurities

≤0.5 mmol/g Cl- (resin)

matrix

crosslinked with 2% DVB

particle size

200-400 mesh

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General description

Dimethylaminomethyl-polystyrene, also known as benzyldimethylamine, is a polystyrene-supported resin crosslinked with divinylbenzene that is commonly used in solution phase peptide synthesis.

Application

Dimethylaminomethyl-polystyrene is used as a resin to synthesize hydrophobic dipeptides such as bis-phenylalanines that can be used in the study of peptide and protein aggregation. Additionally, it can also be utilized for neutralizing acidic solution in a reaction mixture due to its proton reactive nature.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Synthesis of bis-Phenylalanine, A Novel Eight-Membered Cyclic Dipeptide
BV Falcone
Synthetic Communications, 38, 411-418 (2008)
Synthesis and properties of new nucleotide analogues possessing squaramide moieties as new phosphate isosters
K Seio
European Journal of Organic Chemistry (2005)

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