T2020

(±)-α-Tocopherol phosphate disodium salt

water-soluble α-tocopherol analog

• Synonym(s): Alpha Tocopherol phosphate disodium salt
• Linear Formula: C₂₉H₄₉O₅PNa₂
• CAS Number: 60934-46-5
• Molecular Weight: 554.65
• MDL number: MFCD00079579
• UNSPSC Code: 12352205
• eCl@ss: 34058016
• PubChem Substance ID: 24900007
• NACRES: NA.79

Properties

• biological source: synthetic (organic)
• Quality Level: 300
• Assay: ≥97% (HPLC)
• form: powder
• technique(s): HPLC: suitable
• color: white to off-white
• storage temp.: 2-8°C
• SMILES string: [Na].CC(C)CCCC(C)CCCC(C)CCCC1(C)CCc2c(C)c(OP(O)(O)=O)c(C)c(C)c2O1
• InChI: 1S/C29H51O5P.Na.H/c1-20(2)12-9-13-21(3)14-10-15-22(4)16-11-18-29(8)19-17-26-25(7)27(34-35(30,31)32)23(5)24(6)28(26)33-29;;/h20-22H,9-19H2,1-8H3,(H2,30,31,32);;
• InChI key: QRLCTLIPEFQSSG-UHFFFAOYSA-N

Description

Application

(±)-α-Tocopherol phosphate disodium salt has been used as an antioxidant, to assess its protection against oxidative damage in rat hippocampal neurons. It has also been used to study its molecular mechanisms and transport across the plasma membrane.

Biochem/physiol Actions

Tocopherols (TCP) (vitamin E) are a series (α, β, γ and δ) of chiral organic molecules that vary in their degree of methylation of the phenol moiety of the chromanol ring. Tocopherols are lipid soluble anti-oxidants that protect cell membranes from oxidative damage. α-Tocopherol is the form of tocopherol preferentially absorbed by Homo sapiens. α-Tocopherol phosphate (TocP) is used along the α-tocopherol acetate, α-tocopherol-nicotinate, α-tocopherol succinate and other esterified forms as a vitamin E supplement with similar but differential activities.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves