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SML2199

Sigma-Aldrich

L-F001

≥98% (HPLC)

Synonym(s):

5-(3R)-1,2-Dithiolan-3-yl-1-[hexahydro-4-(5-isoquinolinylsulfonyl)-1H-1,4-diazepin-1-yl]-1-pentanone

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About This Item

Empirical Formula (Hill Notation):
C22H29N3O3S3
CAS Number:
1715039-50-1
Molecular Weight:
479.68
UNSPSC Code:
12352200
NACRES:
NA.77
Pricing and availability is not currently available.

Assay

≥98% (HPLC)

form

oil

storage condition

desiccated

color

colorless to light brown

storage temp.

2-8°C

SMILES string

O=C(CCCC[C@@H]1CCSS1)N2CCN(S(C3=CC=CC4=C3C=CN=C4)(=O)=O)CCC2

InChI

1S/C22H29N3O3S3/c26-22(8-2-1-6-19-10-16-29-30-19)24-12-4-13-25(15-14-24)31(27,28)21-7-3-5-18-17-23-11-9-20(18)21/h3,5,7,9,11,17,19H,1-2,4,6,8,10,12-16H2/t19-/m1/s1

InChI key

NWTRUKNNHUXONB-LJQANCHMSA-N

Biochem/physiol Actions

L-F001 is a multifunctional, brain penetrant and potent Rho-associated protein kinase (ROCK) inhibitor that protects the PC12 cells from paraquat induced cytotoxicity. L-F001 suppresses neuroinflammation in vitro and in vivo.
multifunctional, brain penetrant and potent Rho-associated protein kinase (ROCK) inhibitor

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Jingkao Chen et al.
European journal of pharmacology, 806, 1-9 (2017-03-23)
Microglia and astrocytes are largely responsible for inflammatory injury in the brain of Alzheimer's disease (AD). Increasing evidence has indicated that Rho kinase (ROCK) plays an important role in the regulation of neuroinflammation. Previously, we synthesized a new chemical entity
Liting Luo et al.
Neurochemical research, 42(2), 615-624 (2017-01-13)
Amounting evidences demonstrated that Rho/Rho-associated kinase (ROCK) might be a novel target for the therapy of Parkinson's disease (PD). Recently, we synthesized L-F001 and revealed it was a potent ROCK inhibitor with multifunctional effects. Here we investigated the effects of
Wei Shen et al.
Biochemical and biophysical research communications, 464(3), 794-799 (2015-07-19)
Paraquat (PQ) was demonstrated to induce dopaminergic neuron death and is used as a Parkinson's disease (PD) mimetic. Amounting evidences demonstrated that Rho/ROCK may a novel target for the therapy of PD. Previously we synthesized L-F001 and proved it is

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