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S8534

Sigma-Aldrich

Sarsasapogenin

≥98%

Synonym(s):

(25S)-Spirostan-3β-ol, Parigenin

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About This Item

Empirical Formula (Hill Notation):
C27H44O3
CAS Number:
126-19-2
Molecular Weight:
416.64
EC Number:
204-776-3
MDL number:
MFCD00270414
UNSPSC Code:
12352200
PubChem Substance ID:
24899798
NACRES:
NA.25
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Quality Level

200

Assay

≥98%

application(s)

metabolomics
vitamins, nutraceuticals, and natural products

SMILES string

C[C@H]1CC[C@@]2(OC1)O[C@H]3C[C@H]4[C@@H]5CC[C@@H]6C[C@@H](O)CC[C@]6(C)[C@H]5CC[C@]4(C)[C@H]3[C@@H]2C

InChI

1S/C27H44O3/c1-16-7-12-27(29-15-16)17(2)24-23(30-27)14-22-20-6-5-18-13-19(28)8-10-25(18,3)21(20)9-11-26(22,24)4/h16-24,28H,5-15H2,1-4H3/t16-,17-,18+,19-,20+,21-,22-,23-,24-,25-,26-,27+/m0/s1

InChI key

GMBQZIIUCVWOCD-WWASVFFGSA-N

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General description

Sarsasapogenin also known as Sarsagenin or Parigenin, is a steroidal saponin and is the main constituent of Anemarrhena asphodeloides Bunge.[1]

Application

Sarsasapogenin has been used as a synthetic saponin treatment to U-2 OS cells to test its effects in reducing osteosarcoma cell viability and down-regulating YAP and TAZ proteins.[2]

Biochem/physiol Actions

Sarsasapogenin is a well-known multi-target directed ligand (MTDL) for Alzheimer′s disease.[3] It elicits anti-inflammatory, antioxidant, anti-arthritis, anti-asthma, anti-amyloidogenic, neuroprotective, anti-depressant, and anti-cancer properties.[1][3][4] SAR also improves learning and memory ability, loss of neurons in type-1 diabetic rats and protects against diabetic encephalopathy.[1] It is also a therapeutic target for treating ulcerative colitis (UC).[4] SAR as an anti-inflammatory agent improves insulin resistance and adipose tissue inflammation in high-fat diet (HFD)-fed mice.[5]

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000431322
0000431322
0000366482
0000366701
0000366481

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Maria Ferraiuolo et al.
Cancer letters, 433, 18-32 (2018-06-23)
Osteosarcoma (OS) is the most aggressive type of primary solid tumor that develops in bone. Whilst conventional chemotherapy can improve survival rates, the outcome for patients with metastatic or recurrent OS remains poor, so novel treatment agents and strategies are
Yu-Meng Zhang et al.
Phytomedicine : international journal of phytotherapy and phytopharmacology, 91, 153686-153686 (2021-08-02)
A crosstalk exists between diabetes and Alzheimer's disease (AD), and diabetic encephalopathy displays AD-like disorders. Sarsasapogenin (Sar) has strong anti-inflammatory efficacy, showing neuroprotection and memory-enhancement effects. This study aims to verify the ameliorative effects of Sar on diabetic encephalopathy in
Deepa S Mandlik et al.
Immunopharmacology and immunotoxicology, 43(5), 571-583 (2021-08-03)
Ulcerative colitis (UC) is a chronic inflammatory bowel condition considered by oxido-nitrosative stress and the release of pro-inflammatory cytokines that affects the mucosal lining of the colon. Sarsasapogenin (SG), as an active component, has been found in many plants, and
Liwei Wang et al.
Phytochemical analysis : PCA, 22(1), 14-17 (2010-08-28)
Asparagus officinalis L. has several biological activities including antifungal, antiviral and antitumoral activities due to the steroidal saponins. Normally diosgenin and sarsasapogenin are analysed separately by thin-layer chromatography or high-performance liquid chromatography (HPLC-UV or HPLC-ELSD), which is time-consuming and expensive
Yue Liu et al.
Biochemical pharmacology, 175, 113849-113849 (2020-02-16)
Gestational diabetes mellitus (GDM) is associated with an increased risk of progressing to type 2 DM and cardiovascular disease; however, the pathogenesis is still poorly understood. This study was to investigate roles of thrombin and its receptor protease-activated receptor 1
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