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H8885

Sigma-Aldrich

Hydroxyzine dihydrochloride

≥97%

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About This Item

Empirical Formula (Hill Notation):
C21H27ClN2O2 · 2HCl
CAS Number:
2192-20-3
Molecular Weight:
447.83
EC Number:
218-586-3
MDL number:
MFCD00058200
UNSPSC Code:
12161501
PubChem Substance ID:
24895830
NACRES:
NA.77

Assay

≥97%

form

powder

solubility

H2O: soluble
alcohol: soluble
chloroform: soluble

SMILES string

Cl[H].Cl[H].OCCOCCN1CCN(CC1)C(c2ccccc2)c3ccc(Cl)cc3

InChI

1S/C21H27ClN2O2.2ClH/c22-20-8-6-19(7-9-20)21(18-4-2-1-3-5-18)24-12-10-23(11-13-24)14-16-26-17-15-25;;/h1-9,21,25H,10-17H2;2*1H

InChI key

ANOMHKZSQFYSBR-UHFFFAOYSA-N

Gene Information

human ... HRH1(3269)

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General description

Hydroxyzine dihydrochloride (HDH) is the first-generation antihistamine, that belongs to the piperazine class, an H1 receptor antagonist.

Application

Hydroxyzine dihydrochloride has been used in the study of comparative anxiolytic activity of various drugs in experimental models of rats.

Biochem/physiol Actions

Hydroxyzine dihydrochloride (HDH) is used to regulate anxiety. It is also used to treat bronchial asthma and to relax patients before surgery.

Pictograms

Health hazardExclamation mark
GHS08,GHS07

Signal Word

Warning

Hazard Statements

H302,H336,H361d

Hazard Classifications

Acute Tox. 4 Oral - Repr. 2 - STOT SE 3

Target Organs

Central nervous system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Sigma-Aldrich

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Kaori Kimura-Kuroiwa et al.
Journal of anesthesia, 26(3), 422-428 (2012-02-22)
Investigation into the characteristics of anesthetic interactions may provide clues to anesthesia mechanisms. Dexmedetomidine, an α(2)-adrenergic receptor agonist, has become a popular sedative in intensive care, and hydroxyzine, a histamine receptor antagonist, is well known as a tranquilizing premedication for
N Javaud et al.
Annales francaises d'anesthesie et de reanimation, 30(11), 848-850 (2011-10-08)
We are reporting the case of a bradykinin-mediated angioedema, secondary to the angiotensin converting enzyme inhibitors, which delayed treatment could have unfavorably influence the vital prognostic of the patient. Initially, the patient had an isolated edema of the superior lip.
Central nervous system-impairing effects of hydroxyzine as a function of histamine availability.
Silke Conen et al.
Journal of clinical psychopharmacology, 33(2), 276-279 (2013-02-21)
Donatella Marazziti et al.
Current topics in medicinal chemistry, 12(4), 238-253 (2011-12-30)
Anxiety disorders represent the most prevalent psychiatric disorders. In addition, a considerable burden is associated with them, not only for individual sufferers, but also for the health care system. However, many patients who might benefit from treatment are not diagnosed
Byung Hoon Lee et al.
Acta pharmacologica Sinica, 32(9), 1128-1137 (2011-09-06)
To investigate the effects of hydroxyzine on human ether-a-go-go-related gene (hERG) channels to determine the electrolphysiological basis for its proarrhythmic effects. hERG channels were expressed in Xenopus oocytes and HEK293 cells, and the effects of hydroxyzine on the channels were
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Chromatograms

application for HPLC

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