It is recommended to aliquot and store frozen at -20°C following reconstitution. Stock solutions are stable for up to 3 months at -20°C.
C2992
CFTR Inhibitor-172
≥98% (HPLC), powder, CFTR inhibitor
Synonym(s):
5-[(4-Carboxyphenyl)methylene]-2-thioxo-3-[(3-trifluoromethyl)phenyl-4-thiazolidinone
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About This Item
Empirical Formula (Hill Notation):
C18H10F3NO3S2
CAS Number:
Molecular Weight:
409.40
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
Pricing and availability is not currently available.
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Product Name
CFTR(inh)-172, ≥98% (HPLC), powder
Quality Level
Assay
≥98% (HPLC)
form
powder
color
yellow
solubility
DMSO: ≥10 mg/mL
H2O: insoluble
storage temp.
2-8°C
SMILES string
OC(=O)c1ccc(cc1)\C=C2\SC(=S)N(C2=O)c3cccc(c3)C(F)(F)F
InChI
1S/C18H10F3NO3S2/c19-18(20,21)12-2-1-3-13(9-12)22-15(23)14(27-17(22)26)8-10-4-6-11(7-5-10)16(24)25/h1-9H,(H,24,25)/b14-8+
InChI key
JIMHYXZZCWVCMI-RIYZIHGNSA-N
Application
Biochem/physiol Actions
CFTR(inh)-172 is an inhibitor of the cystic fibrosis transmembrane conductance regulator (CFTR).
CFTR(inh)-172 is an inhibitor of the cystic fibrosis transmembrane conductance regulator (CFTR). With a Ki = 300 nM,. CFTR(inh)-172 leads to rapid, reversible and voltage-independent inhibition; it is an antidiarrheal agent in animals. CTFR(inh)-172 may be a useful tool to study animal models of cystic fibrosis and intestinal fluid loss in cholera and other secretory diarrheas. CTFR(inh)-172 is structurally-unrelated to known, but non-specific CFTR inhibitors DPC, NPPB (Cat. No. N4779) and Glibenclamide.
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Product No.
Description
Pricing
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Electrophysiological evaluation of cystic fibrosis conductance transmembrane regulator (CFTR) expression in human monocytes
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N D Sonawane et al.
Journal of pharmaceutical sciences, 94(1), 134-143 (2005-03-12)
A small-molecule inhibitor of the cystic fibrosis transmembrane conductance regulator (CFTR), 3-[(3-trifluoromethyl)phenyl]-5-[(4-carboxyphenyl)methylene]-2-thioxo-4-thiazolidinone (CFTR(inh)-172), reduces enterotoxin-induced intestinal fluid secretion in rodents. Here, we study CFTR(inh)-172 pharmacology and antidiarrheal efficacy in rodents using (14)C-labeled CFTR(inh)-172, liquid chromatography/mass spectrometry, and a closed intestinal
Defective CFTR expression and function are detectable in blood monocytes: development of a new blood test for cystic fibrosis
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Secretory diarrhea is the leading cause of infant death in developing countries and a major cause of morbidity in adults. The cystic fibrosis transmembrane conductance regulator (CFTR) protein is required for fluid secretion in the intestine and airways and, when
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Bonjour, J'aurai voulu connaitre la stabilité de l'inhibiteur après plusieurs mois après qu'elle soit stocké sous forme de solvant. Merci
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