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115M-1

Sigma-Aldrich

CD15 (MMA) Mouse Monoclonal Antibody

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

Quality Level

100
500

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

MMA, monoclonal

description

For In Vitro Diagnostic Use in Select Regions (See Chart)

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (115M-14)
vial of 0.5 mL concentrate (115M-15)
bottle of 1.0 mL predilute (115M-17)
vial of 1.0 mL concentrate (115M-16)
bottle of 7.0 mL predilute (115M-18)

manufacturer/tradename

Cell Marque™

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100

isotype

IgM

control

Hodgkin lymphoma

shipped in

wet ice

storage temp.

2-8°C

visualization

cytoplasmic, membranous

Gene Information

human ... FUT4(2526)

Related Categories

General description

A positive reaction for CD15 combined with a negative reaction for LCA and other B and T lineage markers provides support for Reed-Sternberg cells found in Hodgkin′s disease. Also this antibody does not detect mesotheliomas making it a more frequently used antibody to distinguish epithelial mesothelioma from adenocarcinoma.

Quality


IVD
IVD
IVD
RUO

Linkage

CD15 Positive Control Slides, Product No. 115S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Preparation Note

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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Certificates of Analysis (COA)

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G S Pinkus et al.
The American journal of pathology, 119(2), 244-252 (1985-05-01)
Monoclonal antibody to Leu-M1, a granulocyte-related differentiation antigen, represents a highly effective reagent for detection of diagnostic Reed-Sternberg (R-S) cells and variants in paraffin-embedded tissues of Hodgkin's disease. In 69 of 73 cases of Hodgkin's disease (41 nodular sclerosis, 25
S H Swerdlow et al.
American journal of clinical pathology, 85(3), 283-288 (1986-03-01)
Leu-M1, or MMA, originally was proposed as a differentiation antigen on myelomonocytic cells and was said to be useful as an aid in distinguishing lymphoid from myeloid leukemias. Subsequently, it was proposed by Hsu and Jaffe as a useful marker
K Skubitz, et al.
Leucocyte Typing IV, 800-805 (1989)
S M Hsu et al.
American journal of clinical pathology, 82(1), 29-32 (1984-07-01)
It has been suggested that the malignant cells of Hodgkin's disease (HD), Reed-Sternberg cells, and their mononuclear variants may be related to cells of the monocyte-histiocyte system. To test this hypothesis, 20 cases of HD were tested with nine antibodies
R Wieczorek et al.
The American journal of pathology, 121(3), 374-380 (1985-12-01)
The Leu-M1 antigen has been recently proposed as a valuable immunodiagnostic marker of the Reed-Sternberg cells of Hodgkin's disease and to be particularly helpful is distinguishing Hodgkin's disease from other lymphoproliferative disorders such as peripheral T-cell lymphomas. In this study

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