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Archives of animal nutrition, 67(2), 134-146 (2013-03-26)
Deoxynivalenol (DON) is one of the most important trichothecenes, due to its worldwide distribution and common contamination of animal feed. It mainly affects the gastrointestinal tract and the immune system with a high susceptibility for swine. Lipopolysaccharides (LPS) are endotoxins
Consumption of the trichothecene deoxynivalenol (DON) suppresses growth in experimental animals - an adverse effect that was used to establish the tolerable daily intake for this toxin. DON ingestion has been recently found to suppress plasma insulin-like growth factor acid-labile
The systemic effects of the Fusarium toxin deoxynivalenol (DON) and of bacterial lipopolysaccharides (LPS) were studied in male castrated pigs (40.4 ± 3.7 kg) infused intravenously with either DON or LPS alone (100 μg DON/kg/h, 7.5 μg/LPS/kg/h), or together (100
Deoxynivalenol (DON) is a mycotoxin produced by Fusarium species which is commonly found in temperate regions worldwide as a natural contaminant of cereals. It is of great concern not only in terms of economic losses but also in terms of
Toxicon : official journal of the International Society on Toxinology, 66, 31-36 (2013-02-14)
Trichothecenes induce changes in the intestinal barrier function through decreased expression of cell junction proteins and apoptosis of enterocytes. The mitogen activated protein kinases (MAPK) play an important role in the signaling pathways of cell turnover and differentiation. Using ex
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