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A9199

Sigma-Aldrich

2-Amino-2-methyl-1-propanol

BioXtra, ≥95%

Synonym(s):

β-Aminoisobutyl alcohol, AMP

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About This Item

Linear Formula:
(CH3)2C(NH2)CH2OH
CAS Number:
Molecular Weight:
89.14
Beilstein:
505979
EC Number:
MDL number:
UNSPSC Code:
12161700
PubChem Substance ID:
NACRES:
NA.25
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vapor density

3 (vs air)

Quality Level

vapor pressure

<1 mmHg ( 25 °C)

product line

BioXtra

Assay

≥95%

form

liquid

impurities

≤0.005% Phosphorus (P)
≤0.1% Insoluble matter

ign. residue

≤0.1%

refractive index

n20/D 1.4455 (lit.)

pH

11.0-12 (25 °C, 8.9 g/L)

useful pH range

9.0-10.5

pKa (25 °C)

9.7

bp

165 °C (lit.)

mp

24-28 °C (lit.)

solubility

H2O: 0.5 M at 20 °C, clear, colorless

density

0.934 g/mL at 25 °C (lit.)

anion traces

chloride (Cl-): ≤0.05%
sulfate (SO42-): ≤0.05%

cation traces

Al: ≤0.0005%
Ca: ≤0.0005%
Cu: ≤0.0005%
Fe: ≤0.0005%
K: ≤0.005%
Mg: ≤0.0005%
NH4+: ≤0.05%
Na: ≤0.005%
Pb: ≤0.001%
Zn: ≤0.0005%

SMILES string

CC(C)(N)CO

InChI

1S/C4H11NO/c1-4(2,5)3-6/h6H,3,5H2,1-2H3

InChI key

CBTVGIZVANVGBH-UHFFFAOYSA-N

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Application

2-Amino-2-methyl-1-propanol has been used as an component in enzyme assay for screening the alkaline phosphatase activity in sarcoma osteogenic (SaOS-2) cells.[1].

Biochem/physiol Actions

2-Amino-2-methyl-1-propanol is a substituted aliphatic alcohol and is used majorly as a pH balancer in cosmetic formulations.[2] It has phototoxic effect as it can interact and penetrate above the sebum layer. However, it is not carcinogenic.[3]

Pictograms

Corrosion

Signal Word

Danger

Hazard Statements

Hazard Classifications

Aquatic Chronic 3 - Eye Dam. 1 - Skin Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

179.8 °F - closed cup

Flash Point(C)

82.1 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Final amended report on safety assessment on aminomethyl propanol and aminomethyl propanediol
Burnett CL, et al.
International Journal of Toxicology, 28(6), 141S-161S (2009)
Phototoxic assessment of a sunscreen formulation and its excipients: An in vivo and in vitro study
Hossy BH, et al.
Journal of Photochemistry and Photobiology. B, Biology, 173(6), 545-550 (2017)
The morphogenetically active polymer, inorganic polyphosphate complexed with GdCl3, as an inducer of hydroxyapatite formation in vitro
Wang X, et al.
Biochemical Pharmacology, 102(6), 97-106 (2016)
Sontaya Limmatvapirat et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 67(3), 690-698 (2007-06-20)
The objective of this study was to improve the properties of shellac by composite salts formation. The shellac samples were prepared in various salt forms by dissolving them with 2-amino-2-methyl-1-propanol (AMP) and ammonium hydroxide (AMN) at various ratios of AMP:AMN.
Won-Joon Choi et al.
Journal of environmental sciences (China), 21(7), 907-913 (2009-10-30)
The carbon dioxide (CO2) removal efficiency, reaction rate, and CO2 loading into aqueous blended monoethanolamine (MEA) + 2-amino-2-methyl-1-propanol (AMP) solutions to enhance absorption characteristics of MEA and AMP were carried out by the absorption/regeneration process. As a result, compared to

Questions

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  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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