34392
Methyldibromoglutaronitrile
analytical standard
Synonym(s):
1,2-Dibromo-2,4-dicyanobutane, 1-Bromo-1-(bromomethyl)-1,3-propanedicarbonitrile, 2-Bromo-2-(bromomethyl)glutaronitrile
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About This Item
Empirical Formula (Hill Notation):
C6H6Br2N2
CAS Number:
Molecular Weight:
265.93
EC Number:
MDL number:
UNSPSC Code:
85151701
PubChem Substance ID:
NACRES:
NA.24
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grade
analytical standard
Quality Level
shelf life
limited shelf life, expiry date on the label
technique(s)
HPLC: suitable
gas chromatography (GC): suitable
mp
51-55 °C
application(s)
environmental
format
neat
storage temp.
2-8°C
SMILES string
BrCC(Br)(CCC#N)C#N
InChI
1S/C6H6Br2N2/c7-4-6(8,5-10)2-1-3-9/h1-2,4H2
InChI key
DHVLDKHFGIVEIP-UHFFFAOYSA-N
General description
Methyldibromoglutaronitrile (MDBGN) is a bromine-containing preservative and a clinically significant allergen as investigated from animal/human clinical studies.
Methyldibromoglutaronitrile can be generally used as a preservative in the cosmetic industry for many skin care products.
Application
Methyldibromoglutaronitrile may be used as an analytical reference standard for the quantification of the analyte in cosmetic products using ultra performance liquid chromatography (UPLC) coupled to inductively coupled plasma mass spectrometry (ICP-MS) and gas chromatography followed by mass spectrometry technique.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
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Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral - Skin Corr. 1B
Storage Class Code
8A - Combustible corrosive hazardous materials
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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A C De Groot et al.
Journal of the American Academy of Dermatology, 35(5 Pt 1), 743-747 (1996-11-01)
Euxyl K 400 is a preservative system for cosmetics and toiletries that contains phenoxyethanol and methyldibromoglutaronitrile in a 4:1 ratio. In The Netherlands, Italy, and Germany, the prevalence of allergy to Euxyl K 400 has risen in the past 4
Jakob Torp Madsen et al.
Contact dermatitis, 63(4), 209-214 (2010-08-25)
Ethosomes and liposomes are ultra-small vesicles capable of encapsulating drugs and cosmetic ingredients for topical use, thereby potentially increasing bioavailability and clinical efficacy. So far, few reports have suggested that formulation of cosmetic ingredients in vesicular carrier systems may increase
Charlotte Gotthard Mortz et al.
Current opinion in allergy and clinical immunology, 8(5), 428-432 (2008-09-05)
To give selected new information on contact allergy and allergic contact dermatitis with focus on diagnostic procedures and pitfalls. Recent studies dealing with common contact allergens have improved our understanding of the relationship between positive patch tests and the clinical
Annice Heratizadeh et al.
Contact dermatitis, 62(6), 330-337 (2010-06-19)
While the use of methyldibromo glutaronitrile (MDBGN) in leave-on products is clearly associated with high sensitization or elicitation risk, such a clear-cut relation could be questioned with regard to rinse-off products. The objective of this study was to find a
Axel Schnuch et al.
Contact dermatitis, 56(6), 331-337 (2007-06-20)
Although genetic factors probably account for differences in susceptibility to contact allergy, they have not yet been identified, partly due to an insufficient understanding of 'susceptibility'. Regarding polysensitization (PS) as a sign of increased susceptibility, we studied the relationship between
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