Recommended Products
Assay
≥98% (HPLC)
form
lyophilized
mol wt
calculated mol wt 797.82
packaging
pkg of 1 mg
manufacturer/tradename
Millipore
storage condition
desiccated
protect from light
technique(s)
cell based assay: suitable
color
green
shipped in
ambient
storage temp.
−20°C
General description
Increasing evidence suggests that a small population of tumor initiating cells (TIC) or cancer stem cells (CSC) are responsible for tumorigenesis and resistance to conventional anti-cancer therapies. Heme oxygenase 2 (HMOX2) has recently been identified as a novel biomarker for tumor initiating cells. BioTracker TiNIR HMOX2 Live Cell Dye is a near-infrared (NIR) fluorescent probe for the detection and isolation of HMOX2 expressing tumor initiating cells. At low concentrations or a single injection of high concentration, TiNIR (tumor initiating cell probe with near infrared) is useful for the isolation of TIC in vitro and in vivo visualization in tumor model animals, respectively. At high concentrations or repeated treatments, TiNIR has been shown to inhibit the function of HMOX2 and induce tumor cell death by accumulating ROS in cancer cells .
Spectral Properties
Absorbance: 805 nm
Emission: 825 nm
Reference:1. Kim, J. J., Lee, Y. A., Su, D., Lee, J., Park, S. J., Kim, B., ... & Chang, Y. T. (2019). A near-infrared probe tracks and treats lung tumor initiating cells by targeting HMOX2. Journal of the American Chemical Society, 141(37), 14673-14686.
Spectral Properties
Absorbance: 805 nm
Emission: 825 nm
Reference:1. Kim, J. J., Lee, Y. A., Su, D., Lee, J., Park, S. J., Kim, B., ... & Chang, Y. T. (2019). A near-infrared probe tracks and treats lung tumor initiating cells by targeting HMOX2. Journal of the American Chemical Society, 141(37), 14673-14686.
Application
Purity ≥ 98% confirmed by HPLC. Identification confirmed by HNMR, LC-MS, and elemental analysis.
Features and Benefits
Near-Infrared probe for detection and isolation of HMOX2 expressing tumor initiating cells.
Physical form
Lyophilized. Green solid.
Storage and Stability
Store at -20°C, desiccate and protect from light
Note: Centrifuge vial briefly to collect contents at bottom of vial before opening
Note: Centrifuge vial briefly to collect contents at bottom of vial before opening
Other Notes
Live cell fluorescent imaging
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Jong-Jin Kim et al.
Journal of the American Chemical Society, 141(37), 14673-14686 (2019-08-23)
Tumor initiating cells (TIC) are resistant to conventional anticancer therapy and associated with metastasis and relapse in cancer. Although various TIC markers and their antibodies have been proposed, it is limited to the use of antibodies for in vivo imaging
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service