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810188P

Avanti

TopFluor™ TMR PI

Avanti Research™ - A Croda Brand 810188P, powder

Synonym(s):

TopFluor™ TMR PI, 1-oleoyl-2-(6-((4,4-difluoro-1,3-dimethyl-5-(4-methoxyphenyl)-4-bora-3a,4a-diaza-s-indacene-2-propionyl)amino)hexanoyl)-sn-glycero-3-phosphoinositol (Ammonium salt)

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About This Item

CAS Number:
2260795-35-3
UNSPSC Code:
12352211
NACRES:
NA.25

Assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 50 μg (with stopper and crimp cap (810188P-50ug))

manufacturer/tradename

Avanti Research™ - A Croda Brand 810188P

shipped in

dry ice

storage temp.

−20°C

General description

Phosphatidylinositol (PI) is commonly found in animal tissues and bacteria. PI is soluble in water and chloroform/methanol. TopFluor™ TMR PI is a tetramethylrhodamine (TMR)-labeled fluorescent phospholipid.

Application

TopFluor™ TMR PI has been used in fluorescence quenching of 1-palmitoyl-2-{12-[(7-nitro-2−1,3-benzoxadiazol-4-yl)amino]dodecanoyl}-sn-glycero-3-phosphatidylcholine (NBD PC) in ternary mixtures of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphatidylcholine (POPC)/ 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphatidylethanolamine(POPE)/ soy l-α-phosphatidylinositol (PI) vesicles.

Biochem/physiol Actions

TopFluor™-labeled lipids have spectral properties similar to tetramethylrhodamine (TMR).

Packaging

2 mL Amber Serum Vial with Stopper and Crimp Cap (810188P-50ug)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC
TopFluor is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

No data available

Flash Point(C)

No data available

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Lipids of membranes: Chemistry, biological role and applications as drug carriers
Hatziantonioy S and Demetzos C
Studies in Natural Products Chemistry, 34, 173-202 (2008)
Reorganization of Ternary Lipid Mixtures of Nonphosphorylated Phosphatidylinositol Interacting with Angiomotin
Kimble-Hill, et al.
The Journal of Physical Chemistry B, 122(35), 8404-8415 (2018)
Yi Wen et al.
Biophysical journal, 114(11), 2630-2639 (2018-06-07)
Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2 or PIP2), is a key component of the inner leaflet of the plasma membrane in eukaryotic cells. In model membranes, PIP2 has been reported to form clusters, but whether these locally different conditions could give rise to
Ann C Kimble-Hill et al.
The journal of physical chemistry. B, 122(35), 8404-8415 (2018-06-08)
Phosphatidylinositol (PI) lipids are necessary for many cellular signaling pathways of membrane associated proteins, such as angiomotin (Amot). The Amot family regulates cellular polarity, growth, and migration. Given the low concentration of PI lipids in these membranes, it is likely

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