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QBD11028

Sigma-Aldrich

MAL-dPEG ®12-DSPE

Synonym(s):

Polyethylene glycol

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About This Item

Empirical Formula (Hill Notation):
C75H140N3O24P
Molecular Weight:
1498.89
MDL number:
MFCD28118974
UNSPSC Code:
51171641
NACRES:
NA.22
Pricing and availability is not currently available.

Assay

>90%

form

solid or viscous liquid

reaction suitability

reagent type: cross-linking reagent
reagent type: payload delivery reagent

functional group

phospholipid

polymer architecture

shape: linear
functionality: monofunctional

shipped in

ambient

storage temp.

−20°C

SMILES string

[P](=O)(OC[C@H](OC(=O)CCCCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCCCC)(OCCNC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CCN1C(=O)C=CC1=O)O

InChI

1S/C75H140N3O24P/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-74(83)99-67-69(102-75(84)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2)68-101-103(85,86)100-44-40-77-71(80)38-42-87-45-47-89-49-51-91-53-55-93-57-59-95-61-63-97-65-66-98-64-62-96-60-58-94-56

InChI key

NSUQHFQCPXYHBT-UPFDQZFOSA-N

Related Categories

Features and Benefits

MAL-dPEG®₁₂-DSPE is a micelle building block which can react with a free thiol through the maleimide.

Legal Information

Products Protected under U.S. Patents # 7,888,536 B2
dPEG is a registered trademark of Quanta BioDesign

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Questions

  1. Can this linker insert, with the lipid part, into a hydrophobic structure (e.g. a liposome) and, with the maleimide, bind a protein? In other words, can this linker be used to conjugate a protein to a liposome? If so, how to do it?

    1 answer

    1. The maleimide group in this linker reacts with a free thiol to form a thiosuccinimide, as illustrated by the mechanism provided in the link below.

      https://vectorlabs.com/maleimide-reaction-chemistry?srsltid=AfmBOooW0TaVJgwiB3kh9BX5yB7bbe0l-qe2r5Jg4s50QeQv4WxqdVkd

      After conjugating to a thiol-containing protein, it is important to consider the encapsulation or functionalization methods for a liposome. This application necessitates a review of existing scientific literature to develop this application. Below is some information that should be helpful to you that discusses this in more detail, describing postinsertion methods and strategies for adsorbing onto vector surfaces.

      https://pmc.ncbi.nlm.nih.gov/articles/PMC3418104/

      Helpful?

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