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197017

Sigma-Aldrich

4-Chloro-3,5-dinitrobenzotrifluoride

98%

Synonym(s):

CDNT, DNT-Cl

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About This Item

Linear Formula:
ClC6H2(NO2)2CF3
CAS Number:
393-75-9
Molecular Weight:
270.55
Beilstein:
1220937
EC Number:
206-889-3
MDL number:
MFCD00007068
UNSPSC Code:
12352100
PubChem Substance ID:
24851818
NACRES:
NA.22

Assay

98%

form

solid

mp

50-55 °C (lit.)

solubility

water: insoluble

SMILES string

[O-][N+](=O)c1cc(cc(c1Cl)[N+]([O-])=O)C(F)(F)F

InChI

1S/C7H2ClF3N2O4/c8-6-4(12(14)15)1-3(7(9,10)11)2-5(6)13(16)17/h1-2H

InChI key

HFHAVERNVFNSHL-UHFFFAOYSA-N

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Application

4-Chloro-3,5-dinitrobenzotrifluoride was used:
  • as derivatization reagent in determination of amikacin in water samples and amino acids by HPLC
  • in the synthesis of N-(2,6-dinitro-4-trifluoromethylphenyl)aniline derivatives
  • in the synthesis of 4,6-dinitro-2,8-bis(trifluoromethyl)phenothiazine and isopropyl-2,6-dinitro-4-trifluoromethylphenyl sulfide

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H302,H310,H315,H319

Hazard Classifications

Acute Tox. 2 Dermal - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point(F)

258.8 °F - closed cup

Flash Point(C)

126 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Biren A Patel et al.
Journal of human evolution, 108, 176-198 (2017-06-18)
Songhor is an early Miocene fossil locality in Kenya known for its diverse primate assemblage that includes catarrhine species belonging to the genera Kalepithecus, Limnopithecus, Dendropithecus, Rangwapithecus, and Proconsul. Expeditions to Songhor since the 1930s have recovered unassociated catarrhine postcranial
K A Werbovetz et al.
Molecular and biochemical parasitology, 98(1), 53-65 (1999-02-24)
Past work suggests that tubulin from kinetoplastid parasites may present an excellent drug target. To explore this possibility, tubulin was purified on a milligram scale from Leishmania mexicana amazonensis promastigotes by sonication, DEAE-Sepharose chromatography, and one cycle of assembly-disassembly. Purified
Tianyu Shi et al.
Analytica chimica acta, 654(2), 154-161 (2009-10-27)
This work presents an high-performance liquid chromatography method for the determination of amino acids after precolumn derivatization with 4-chloro-3,5-dinitrobenzotrifluoride (CNBF) which can readily react with both primary and secondary amines. The precolumn derivatization conditions, including the CNBF concentration, reaction pH
S W Kamau et al.
BMC pharmacology, 1, 1-1 (2001-04-12)
Leishmaniasis is a major parasitic disease in the tropical regions. However, Leishmania infantum has recently emerged as a very important cause of opportunistic infections for individuals positive for human immunodeficiency virus (HIV). However, there is a lack of in vitro
In vitro effects of substituted toluenes on mitochondria isolated from rat liver.
C M Schiller
Biochemical pharmacology, 29(18), 2485-2489 (1980-09-15)
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