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USP

Simethicone

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

α-(Trimethylsilyl)-ω-methylpoly[oxy(dimethylsilylene)] mixture with silicon dioxide, Antifoam A, Antifoam AF

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About This Item

CAS Number:
8050-81-5
UNSPSC Code:
41116107
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

simethicone

manufacturer/tradename

USP

application(s)

pharmaceutical (small molecule)

format

neat

InChI

1S/C6H18O2Si2.O2Si/c1-7-10(5,6)8-9(2,3)4;1-3-2/h1-6H3;

InChI key

AMTWCFIAVKBGOD-UHFFFAOYSA-N

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Simethicone comprises a combination of linear siloxane polymers that are fully methylated and consist of repeating units represented by the formula [–(CH3)2SiO–]n. The polymer is further stabilized using trimethylsiloxy end-blocking units denoted by the formula [(CH3)3SiO–], along with silicon dioxide.

Application

Simethicone USP reference standard suitable for use in specified USP compendial tests and assays.

Also used to prepare standard solutions for impurity analysis in Simethicone using the IR technique according to the United States Pharmacopeia (USP) monograph.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

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Description
Pricing

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Simethicone
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 30(4), 4042-4042 (2020)
Hong-bin Chen et al.
Journal of clinical gastroenterology, 45(4), 337-341 (2010-09-28)
There is no consensus concerning small bowel preparation before capsule endoscopy (CE). This study evaluated the effects of 4 regimens on small bowel cleansing and diagnostic yield. Patients were randomly divided into 4 groups. Group A consumed a clear liquid
Sita V Jansen et al.
European journal of gastroenterology & hepatology, 23(10), 897-902 (2011-09-09)
A good bowel preparation is essential for optimal visualization of the large intestine. Several preparations with a difference in composition and volume are available. We compared five methods for bowel cleansing quality and patients' acceptability. Adult ambulatory outpatients scheduled for
Benoit Coffin et al.
Clinics and research in hepatology and gastroenterology, 35(6-7), 494-499 (2011-04-12)
A simethicone, activated charcoal and magnesium oxide combination (Carbosymag(®)) has been used for almost 20 years in functional dyspepsia, but there is limited scientific evidence of efficacy. We evaluated the efficacy of Carbosymag(®) in 18- to 49-year-old patients with functional
H N Kim et al.
Gastrointestinal endoscopy clinics of North America, 20(3), 437-448 (2010-07-27)
Colonoscopy is considered the gold standard for colon cancer screening. In a recent study, however, 0.3% to 0.9% patients developed colorectal cancer within 3 years after removal of adenomas. Some reasons for the development of interval colorectal cancers include missed
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