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SML3664

Sigma-Aldrich

BTD

≥98% (HPLC)

Synonym(s):

6-​methyl-​N-​[3-​(tricyclo[3.3.1.13,​7]​dec-​1-​yloxy)​propyl]​-​4H-​1,​2,​4-​benzothiadiazine-​3-​propanamide 1,​1-​dioxide, N-[3-(adamantan-2-yloxy)propyl]-3-(6-methyl-1,1-dioxo-2H-1λ6,2,4-benzothiadiazin-3-yl)propanamide

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About This Item

Empirical Formula (Hill Notation):
C24H33N3O4S
CAS Number:
896684-04-1
Molecular Weight:
459.60
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

-10 to -25°C

SMILES string

O=C(NCCCOC1(C2)C[C@H](C[C@H]2C3)C[C@H]3C1)CCC(NS4(=O)=O)=NC5=C4C=CC(C)=C5

Biochem/physiol Actions

BTD is a potent and selective activator of the transient receptor potential canonical channel 5 (TRPC5). BTD can also activate heteromeric channels composed of TRPC5 and its closest relatives TRPC1 or TRPC4.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Holger Beckmann et al.
Cell calcium, 66, 10-18 (2017-08-16)
The transient receptor potential canonical channel 5 (TRPC5) is a Ca2+-permeable ion channel, which is predominantly expressed in the brain. TRPC5-deficient mice exhibit a reduced innate fear response and impaired motor control. In addition, outgrowth of hippocampal and cerebellar neurons
Aisling Minard et al.
Cells, 7(6) (2018-06-06)
Proteins of the TRPC family can form many homo- and heterotetrameric cation channels permeable to Na⁺, K⁺ and Ca2+. In this review, we focus on channels formed by the isoforms TRPC1, TRPC4 and TRPC5. We review evidence for the formation

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