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SML3583

Sigma-Aldrich

PF-04634817 succinate

≥98% (HPLC)

Synonym(s):

1,​5-​Anhydro-​2,​3-​dideoxy-​4-​O-​methyl-​3-​[[(1R,​3S)​-​3-​(1-​methylethyl)​-​3-​[[(1S,​4S)​-​5-​[6-​(trifluoromethyl)​-​4-​pyrimidinyl]​-​2,​5-​diazabicyclo[2.2.1]​hept-​2-​yl]​carbonyl]​cyclopentyl]​amino]​-D-​erythro-​pentitol succinate

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5 MG
₹11,528.63
25 MG
₹46,471.73

₹11,528.63


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5 MG
₹11,528.63
25 MG
₹46,471.73

About This Item

Empirical Formula (Hill Notation):
C25H36F3N5O3 · C4H6O4
CAS Number:
Molecular Weight:
629.67
MDL number:
UNSPSC Code:
51111800
UNSPSC Code:
12352200
NACRES:
NA.77

₹11,528.63


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Quality Level

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

room temp

SMILES string

CO[C@H]1[C@@H](N[C@@H]2CC[C@@](C(N3C[C@@]4([H])N(C5=NC=NC(C(F)(F)F)=C5)C[C@]3([H])C4)=O)(C(C)C)C2)CCOC1

InChI key

MCRWZBYTLVCCJJ-DKALBXGISA-N

Biochem/physiol Actions

Orally available, potent and selective CCR2/5 receptor antagonist

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Identification of Molecular Signatures and Candidate Drugs in Vascular Dementia by Bioinformatics Analyses
Shu J, Wei W, Zhang L
Frontiers in Molecular Neuroscience, 15, 751044-751044 (2022)
Effect of PF-04634817, an Oral CCR2/5 Chemokine Receptor Antagonist, on Albuminuria in Adults with Overt Diabetic Nephropathy
Gale JD, Gilbert S, Blumenthal S, Elliott T, Pergola PE, Goteti K, Scheele W, Perros-Huguet C
Kidney international reports, 3, 1316-1327 (2018)

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