Skip to Content
Merck
All Photos(1)

Key Documents

View All Documentation

SML2996

Sigma-Aldrich

SR-301

≥98% (HPLC)

Synonym(s):

6-(1H-Imidazol-1-yl)-N-[2-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-3-pyridazinecarboxamide, N-(2-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)phenyl)-6-(1H-imidazol-1-yl)pyridazine-3-carboxamide, SR 301, SR301

Sign Into View Organizational & Contract Pricing

Select a Size

5 MG
₹8,746.60
25 MG
₹38,060.70

₹8,746.60

Estimated to ship on16 April 2025Details

Request a Bulk Order
All Photos(1)

Select a Size

Change View
5 MG
₹8,746.60
25 MG
₹38,060.70

About This Item

Empirical Formula (Hill Notation):
C17H11F6N5O2
CAS Number:
2375419-35-3
Molecular Weight:
431.29
UNSPSC Code:
51111800
NACRES:
NA.77

₹8,746.60

Estimated to ship on16 April 2025Details

Request a Bulk Order

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

−20°C

SMILES string

O=C(C1=NN=C(N2C=NC=C2)C=C1)NC3=C(C(O)(C(F)(F)F)C(F)(F)F)C=CC=C3

InChI key

COFASYKPDRGFKT-UHFFFAOYSA-N

Biochem/physiol Actions

Orally bioavailable analog of the selective STING agonist SR-717 with good antitumor efficacy in a murine B16.F10 melanoma tumor model in vivo.
SR-301 is an orally bioavailable analog of the selective STING agonist SR-717. SR-301 shows higher potency than SR-717 by THP1-based ISRE reporter assay (EC50 = 0.6 vs. 2.1 μM, respectively) and shows good antitumor efficacy when administered orally in a murine B16.F10 melanoma tumor model in vivo (15 mg/kg/day p.o.).

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
0000123824
0000123825
0000120358

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Emily N Chin et al.
Science (New York, N.Y.), 369(6506), 993-999 (2020-08-21)
Stimulator of interferon genes (STING) links innate immunity to biological processes ranging from antitumor immunity to microbiome homeostasis. Mechanistic understanding of the anticancer potential for STING receptor activation is currently limited by metabolic instability of the natural cyclic dinucleotide (CDN)

Questions

Reviews

No rating value

Active Filters

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service