SML2806

MALAT1-IN-5

≥95% (HPLC)

• Synonym(s): 5-(4-Methoxyphenyl)-N-[(3-methoxyphenyl)methyl]-1-methyl-1H-imidazol-2-amine, Malat1 inhibitor compound 5, N-(3-Methoxybenzyl)-5-(4-methoxyphenyl)-1-methyl-1H-imidazol-2-amine, TC SL C5
• Empirical Formula (Hill Notation): C₁₉H₂₁N₃O₂
• CAS Number: 827327-28-6
• Molecular Weight: 323.39
• MDL number: MFCD06011226
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥95% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: −20°C
• SMILES string: [n]1(c(ncc1c3ccc(cc3)OC)NCc2cc(ccc2)OC)C
• InChI: 1S/C19H21N3O2/c1-22-18(15-7-9-16(23-2)10-8-15)13-21-19(22)20-12-14-5-4-6-17(11-14)24-3/h4-11,13H,12H2,1-3H3,(H,20,21)
• InChI key: LCVOJBGSGIOMKF-UHFFFAOYSA-N

Description

Biochem/physiol Actions

MALAT1-IN-5 reduces the long noncoding (lnc) RNA metastasis-associated lung adenocarcinoma transcript 1 (Malat1) level (by 54% in 7 days at 1 μM; MMTV-PyMT tumors organoids) via specific interaction with Malat1 triple-helical configuration of 3′-terminal element for nuclear expression (ENE KD = 2.9 μM under physiologic ionic conditions), but not the homologous 3′-end triple-helix of Neat1 (MENβ) lncRNA. MALAT1-IN-5 decreases MMTV-PyMT organoid branching morphogenesis (by 38% in 7 days at 1 μM) and modulates the levels of Malat1-targeted mRNAs Krt16 & Csn2.

Selective metastasis-associated lung adenocarcinoma transcript 1 inhibitor that decreases tumor organoid branching and modulates Malat1-targeted mRNAs.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable