SML1326

PK-THPP

≥98% (HPLC)

• Synonym(s): 1-[1-[6-([1,1′-Biphenyl]-4-ylcarbonyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl]-4-piperidinyl]-1-butanone
• Empirical Formula (Hill Notation): C₂₉H₃₂N₄O₂
• CAS Number: 1332454-07-5
• Molecular Weight: 468.59
• MDL number: MFCD28396418
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825786
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: H₂O: 10 mg/mL, clear; DMSO: 2 mg/mL, clear (warmed)
• storage temp.: 2-8°C
• SMILES string: O=C(CCC)C(CC1)CCN1C2=C3C(CCN(C(C4=CC=C(C5=CC=CC=C5)C=C4)=O)C3)=NC=N2
• InChI: 1S/C29H32N4O2/c1-2-6-27(34)23-13-16-32(17-14-23)28-25-19-33(18-15-26(25)30-20-31-28)29(35)24-11-9-22(10-12-24)21-7-4-3-5-8-21/h3-5,7-12,20,23H,2,6,13-19H2,1H3
• InChI key: CJZGRIRZVHNUSM-UHFFFAOYSA-N

Description

Biochem/physiol Actions

PK-THPP is a potent antagonist of tandem pore potassium channel subunit TASK-3 (KCNK9, K2P9.1) with an IC₅₀ value of 35 nM for TASK-3 compared to 303 nM for TASK-1 and with >140 fold selectivity over a wider range of potassium channels. PK-THPP was found to act as a respiratory stimulant, stimulating breathing in isoflurane-anesthetized rats.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable