SML1163

UNC2881

≥98% (HPLC)

• Synonym(s): 2-(Butylamino)-4-[(trans-4-hydroxycyclohexyl)amino]-N-[[4-(1H-imidazol-1-yl)phenyl]methyl]-5-pyrimidinecarboxamide
• Empirical Formula (Hill Notation): C₂₅H₃₃N₇O₂
• CAS Number: 1493764-08-1
• Molecular Weight: 463.58
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825693

Properties

• Assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 20 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: O[C@@H](CC1)CC[C@H]1NC2=C(C(NCC3=CC=C(N4C=NC=C4)C=C3)=O)C=NC(NCCCC)=N2
• InChI: 1S/C25H33N7O2/c1-2-3-12-27-25-29-16-22(23(31-25)30-19-6-10-21(33)11-7-19)24(34)28-15-18-4-8-20(9-5-18)32-14-13-26-17-32/h4-5,8-9,13-14,16-17,19,21,33H,2-3,6-7,10-12,15H2,1H3,(H,28,34)(H2,27,29,30,31)/t19-,21-
• InChI key: NPVXOWLPOFYACO-XUTJKUGGSA-N

Description

Biochem/physiol Actions

UNC2881 is a selective inhbitor of Mer kinase, a member of the TAM (Tyro3, Axl, Mer) receptor tyrosine kinase family. The IC₅₀ values for inhibition of Mer, Axl and Tyro 3 are 4.3, 360 and 250 nM, respectively.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H302
• Precautionary Statements: P301 + P312 + P330
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class Code: 13 - Non Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable