SAB4700562
Monoclonal Anti-Cd86-FITC antibody produced in rat
clone GL-1, purified immunoglobulin, buffered aqueous solution
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.44
biological source
rat
conjugate
FITC conjugate
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
GL-1, monoclonal
form
buffered aqueous solution
species reactivity
mouse
concentration
0.5 mg/mL
technique(s)
flow cytometry: suitable
isotype
IgG2a
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
2-8°C
Gene Information
mouse ... Cd86(12524)
General description
Cluster of differentiation 86 (CD86), also known as B7-2, is encoded by the gene mapped to human chromosome 3q13.33. CD86 is a co-stimulatory molecule expressed on various immune cells. The encoded protein belongs to the immunoglobulin (Ig) superfamily.
The rat monoclonal antibody GL-1 reacts with CD86 (B7-2), a 70-80 kDa type I transmembrane glycoprotein of immunoglobulin supergene family, expressed on professional antigen-presenting cells, such as dendritic cells, macrophages or activated B lymphocytes.
Immunogen
LPS-activated CBA/Cs mouse splenic B cells
Application
The reagent is designed for Flow Cytometry analysis. Suggested working dilution is 2 μg/mL of sample. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator.
Biochem/physiol Actions
Cluster of differentiation 86 (CD86) plays a vital role in immune responses. Mutations in the gene leads to the development of pneumonia-induced sepsis by downregulating CD86 gene expression in monocytes. Additionally, genetic variation in the gene increases the risk of susceptibility to colorectal cancer.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Solution in phosphate buffered saline, pH 7.4, with 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
12 - Non Combustible Liquids
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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MicroRNA binding site polymorphisms as biomarkers of cancer risk.
Pelletier C and Weidhaas JB
Expert Review of Molecular Diagnostics, 10, 817-829 (2010)
B7-H3: a costimulatory molecule for T cell activation and IFN-gamma production.
Chapoval Al
Nature Immunology, 2, 269-274 (2001)
Distinct role of CD86 polymorphisms (rs1129055, rs17281995) in risk of cancer: evidence from a meta-analysis.
Geng P
PLoS ONE, 9 (2014)
CD86 polymorphism affects pneumonia-induced sepsis by decreasing gene expression in monocytes.
Song H
Inflammation, 38, 879-885 (2015)
Wen-Horng Wang et al.
ImmunoHorizons, 3(7), 254-261 (2019-07-30)
The SYK protein-tyrosine kinase is a well-known mediator of signals elicited by the clustering of BCR complexes and other receptors that bear components that contain one or more ITAM sequences. Additional roles for the kinase in signaling through other receptor
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