Human polo-like kinase 1 (PLK1) is a serine/threonine kinase, that is located on human chromosome 16p12.
Immunogen
The antiserum was produced against synthesized peptide derived from human PLK1 around the phosphorylation site of Thr210.
Immunogen Range: 176-225
Biochem/physiol Actions
Polo-like kinase 1 (PLK1) plays an important role in the functional maturation of mitotic centrosomes. It actively participates in the development of the cell cycle. This gene is considered as an important therapeutic target as it is overexpressed in several cancer types.
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Antibody microinjection reveals an essential role for human polo-like kinase 1 (Plk1) in the functional maturation of mitotic centrosomes
H A Lane and E A Nigg
The Journal of Cell Biology, 1701-1713 (1996)
Polo on the Rise-from Mitotic Entry to Cytokinesis with Plk1
Petronczki M, et al.
Developmental Cell, 14(5), 646-659 (2008)
Drug sensitivity and resistance testing identifies PLK1 inhibitors and gemcitabine as potent drugs for malignant peripheral nerve sheath tumors
Kolberg M, et al.
Molecular Oncology, 11(9), 1156-1171 (2017)
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