Ribosomal protein L39 (RPL39), a component of the 60S ribosomal complex. The RPL39 gene is mapped on human chromosome XQ24.
Immunogen
The antiserum was produced against synthesized peptide derived from human RPL39.
Immunogen Range: 1-50
Biochem/physiol Actions
Ribosomal protein L39 (RPL39) plays a major role in spermatogenesis and translation. It might participate in ribosome biogenesis. Mutations in the RPL39 gene are associated with breast cancer and lung metastasis. RPL39 is capable of disrupting nitric oxide synthase and hypoxia signaling pathway. Overexpression of RPL39 can enhance wound-healing in MDAMB231 and BT549 cells. Antibody detects endogenous levels of total RPL39 protein.
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Proceedings of the National Academy of Sciences of the United States of America, 111(24), 8838-8843 (2014-05-31)
We previously described a gene signature for breast cancer stem cells (BCSCs) derived from patient biopsies. Selective shRNA knockdown identified ribosomal protein L39 (RPL39) and myeloid leukemia factor 2 (MLF2) as the top candidates that affect BCSC self-renewal. Knockdown of
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