Anti-Progesterone receptor antibody detects endogenous levels of total progesterone receptor protein.
The progesterone receptor (PR) gene is mapped to human chromosome 11q22–23. The gene encodes for two isoforms, namely PR-A and PR-B, each of which is transcribed from a specific promoter region. The encoded receptor belongs to the family of steroid hormone receptors.
Immunogen
The antiserum was produced against synthesized peptide derived from human Progesterone Receptor.
Immunogen Range: 261-310
Application
Anti-Progesterone receptor antibody produced in rabbit has been used in western blotting and immunohistochemistry.
Biochem/physiol Actions
Progesterone receptor (PR) mediates the actions of progesterone which is essential to maintain pregnancy. PR is known to regulate the genes involved in the process of cell cycle, cell adhesion, invasion, differentiation, proliferation, inflammation, and apoptosis. PR expression might serve as a biomarker in axillary lymph node (ALN) metastasis. Abnormal expression of PR is observed in breast cancer.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
CCAAT/enhancer binding protein ? negatively regulates progesterone receptor expression in human glioblastoma cells.
Hansberg-Pastor V
Molecular and Cellular Endocrinology, 439, 317-327 (2017)
Rapid impact of progesterone on the neuronal growth cone.
Olbrich L.
Endocrinology, 154(10), 3784-3795 (2013)
Absent progesterone receptor expression in the lymph node metastases of ER-positive, HER2-negative breast cancer is associated with relapse on tamoxifen.
Snell CE
Journal of Clinical Pathology, 70(11), 954-960 (2017)
No association between the progesterone receptor gene polymorphism (+331G/a) and the risk of breast cancer: an updated meta-analysis.
Qi XL
BMC Medical Genetics, 18(1):123, 1-7 (2017)
Akt regulates progesterone receptor B-dependent transcription and angiogenesis in endometrial cancer cells.
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
