SAB3500070

Anti-THEM2 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

• Synonym(s): Anti-ACOT13, Anti-Acyl-CoA thioesterase 13, Anti-PNAS-27, Anti-Thioesterase superfamily member 2
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• species reactivity: rat, mouse, human
• technique(s): immunofluorescence: suitable; immunohistochemistry: suitable; indirect ELISA: suitable; western blot: suitable
• NCBI accession no.: NP_060943
• UniProt accession no.: Q9NPJ3
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... ACOT13(55856)

Description

General description

Acyl-CoA thioesterase 13 (ACOT13), also known as thioesterase superfamily member 2 (THEM-2), is encoded by the gene mapped to human chromosome 6p22.3. The encoded protein has a molecular mass of ∼15kDa with 140 amino acids. It is a member of the hotdog-domain thioesterase family. THEM2 is highly expressed in several tissues such as heart, kidney, liver and brown adipose tissue (BAT). It has been shown to be co-localized with β-tubulin on microtubules. At least two isoforms of THEM2 are known to exist.

Immunogen

THEM2 antibody was raised against a 17 amino acid peptide near the carboxy terminus of human THEM2.

Biochem/physiol Actions

Acyl-CoA thioesterase 13 (ACOT13)/thioesterase superfamily member 2 (THEM-2) possesses thioesterase activity, with greater activity observed with longer chain acyl-CoAs such as myristoyl- and palmitoyl-CoA. THEM2 associates with StarD, a protein that plays a key role in fatty acid metabolism, and the addition of StarD to THEM2 increased its catalytic activity, suggesting that THEM2 plays a significant role in the metabolism of fatty acids.

Features and Benefits

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Linkage

The action of this antibody can be blocked using blocking peptide SBP3500070.

Physical form

Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable