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SAB1408913

Sigma-Aldrich

Anti-BNIPL antibody produced in mouse

purified immunoglobulin, buffered aqueous solution

Synonym(s):

BNIP-S, BNIPL-1, BNIPL-2, BNIPL1, BNIPL2, PP753

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 81 kDa

species reactivity

human

technique(s)

western blot: 1 μg/mL

NCBI accession no.

BC074779.2

UniProt accession no.

Q7Z465

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... BNIPL(149428)

Related Categories

General description

BNIPL (BCL2/adenovirus E1B 19kD interacting protein like) is a novel proapoptotic protein belonging to the BNIPL family. It consists of a BNIP-2 and Cdc42GAP homology (BCH) domain. It is expressed in human placenta and lungs.

Immunogen

BNIPL (AAH74779.3, 1 a.a. ~ 275 a.a) full-length human protein.

Sequence
MRKRLSAPELRLSLTKGPGNDGASPTQSAPSSPDGSSDLEIDELETPSDSEQLDSGHEFEWEDELPRAEGLGTSETAERLGRGCMWDVTGEDGHHWRVFRMGPREQRVDMTVIEPYKKVLSHGGYHGDGLNAVILFASCYLPRSSIPNYTYVMEHLFRYMVGTLELLVAENYLLVHLSGGTSRAQVPPLSWIRQCYRTLDRRLRKNLRALVVVHATWYVKAFLALLRPFISSKFTRKIRFLDSLGELAQLISLDQVHIPEAVRQLDRDLHGSGGT

Biochem/physiol Actions

BNIPL (BCL2/adenovirus E1B 19kD interacting protein like) is highly involved in the apoptotic pathways. The BCH domain of BNIPL performs in two critical pathways related to cell death. During DNA fragmentation, it directly interacts with the Bcl-2 as a linker protein. BNIPL also interacts with Cdc42GAP to stabilize the structural changes of chromosome during apoptosis. It has been reported that BNIPL may participate in the regulation of DNA fragmentation and membrane bleb formation pathways in apoptotic cells. BNIPL also plays a crucial role in the cell proliferation by binding to cell proliferation-related proteins, MIF (macrophage migration inhibitory factor) and GFER (growth factor erv1 (Saccharomyces cerevisiae-like).

Physical form

Solution in phosphate buffered saline, pH 7.4

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Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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Li Shen et al.
FEBS letters, 540(1-3), 86-90 (2003-04-12)
Bcl-2/adenovirus E1B 19 kDa interacting protein 2-like, BNIP-2-like (BNIPL) is a recently cloned and characterized apoptosis-associated protein that shares 72% homology with BNIP-2. It is highly expressed in human placenta and lung. A yeast two-hybrid system was used to obtain
Li Xie et al.
World journal of gastroenterology, 10(9), 1286-1291 (2004-04-28)
Bcl-2/adenovirus E1B 19 ku interacting protein 2-like (BNIPL-2) is a novel protein recently identified in our laboratory. BNIPL-2 is homologous to human BNIP-2, a potentially proapoptotic protein, and can interact with Bcl-2 and Cdc42GAP and promote apoptosis in BEL-7402 cells.
Wenxin Qin et al.
Biochemical and biophysical research communications, 308(2), 379-385 (2003-08-07)
The execution phase of apoptosis is characterized by marked changes in cell morphology that include contraction and membrane blebbing. Little is known about the mechanisms underlying this process. We report here the identification of a novel member of BNIPL family

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