SAB1408617
Anti-PFKFB1 antibody produced in rabbit
purified immunoglobulin, buffered aqueous solution
Synonym(s):
F6PK, HL2K, MGC116715, MGC116717, PFRX
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100 μG
₹41,447.40
₹41,447.40
Estimated to ship on07 April 2025Details
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100 μG
₹41,447.40
About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
₹41,447.40
Estimated to ship on07 April 2025Details
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~54.7 kDa
species reactivity
human
technique(s)
immunofluorescence: suitable
western blot: 1 μg/mL
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... PFKFB1(5207)
General description
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 (PFKFB1) is encoded by the gene mapped to human chromosome Xp11.21. The encoded protein is one among the four isoenzymes of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase. PFKFB1 is expressed predominantly in liver.
This gene encodes a member of the family of bifunctional 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase enzymes. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using independent catalytic domains. Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently, regulating fructose-2,6-biphosphate levels through the activity of this enzyme is thought to regulate glucose homeostasis. (provided by RefSeq)
Immunogen
PFKFB1 (NP_002616.1, 1 a.a. ~ 471 a.a) full-length human protein.
Sequence
MSPEMGELTQTRLQKIWIPHSSGSSRLQRRRGSSIPQFTNSPTMVIMVGLPARGKTYISTKLTRYLNWIGTPTKVFNLGQYRREAVSYKNYEFFLPDNMEALQIRKQCALAALKDVHNYLSHEEGHVAVFDATNTTRERRSLILQFAKEHGYKVFFIESICNDPGIIAENIRQVKLGSPDYIDCDREKVLEDFLKRIECYEVNYQPLDEELDSHLSYIKIFDVGTRYMVNRVQDHIQSRTVYYLMNIHVTPRSIYLCRHGESELNIRGRIGGDSGLSVRGKQYAYALANFIQSQGISSLKVWTSRMKRTIQTAEALGVPYEQWKALNEIDAGVCEEMTYEEIQEHYPEEFALRDQDKYRYRYPKGESYEDLVQRLEPVIMELERQENVLVICHQAVMRCLLAYFLDKSSDELPYLKCPLHTVLKLTPVAYGCKVESIYLNVEAVNTHREKPENVDITREPEEALDTVPAHY
Sequence
MSPEMGELTQTRLQKIWIPHSSGSSRLQRRRGSSIPQFTNSPTMVIMVGLPARGKTYISTKLTRYLNWIGTPTKVFNLGQYRREAVSYKNYEFFLPDNMEALQIRKQCALAALKDVHNYLSHEEGHVAVFDATNTTRERRSLILQFAKEHGYKVFFIESICNDPGIIAENIRQVKLGSPDYIDCDREKVLEDFLKRIECYEVNYQPLDEELDSHLSYIKIFDVGTRYMVNRVQDHIQSRTVYYLMNIHVTPRSIYLCRHGESELNIRGRIGGDSGLSVRGKQYAYALANFIQSQGISSLKVWTSRMKRTIQTAEALGVPYEQWKALNEIDAGVCEEMTYEEIQEHYPEEFALRDQDKYRYRYPKGESYEDLVQRLEPVIMELERQENVLVICHQAVMRCLLAYFLDKSSDELPYLKCPLHTVLKLTPVAYGCKVESIYLNVEAVNTHREKPENVDITREPEEALDTVPAHY
Application
Anti-PFKFB1 antibody produced in rabbit has been used in western blotting.
Biochem/physiol Actions
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 (PFKFB1) catalyzes the synthesis and degradation of fructose-2,6-bisphosphate. It plays a vital role in regulation of both glycolysis and gluconeogenesis. PFKFB1 also facilitates cell growth and apoptosis.
Physical form
Solution in phosphate buffered saline, pH 7.4
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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6-Phosphofructo-2-kinase/fructose-2, 6-biphosphatase 4 is essential for p53-null cancer cells.
Ros S, et al.
Oncogene, 36(23), 3287-3287 (2017)
Gene expression analysis of epidermolysis bullosa simplex with mottled pigmentation
Bchetnia M, et al.
Journal of Dermatological Science, 69(1), 80-82 (2013)
A pericentric inversion of chromosome X disrupting F8 and resulting in haemophilia A
Xin Y, et al.
Journal of Clinical Pathology (2017)
R S Batra et al.
Genomics, 40(2), 358-361 (1997-03-01)
6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/FBPase-2) catalyzes the synthesis and degradation of fructose-2,6-bisphosphate, a potent regulator of glycolysis. Previous studies assigned the gene for human liver PFK-2/FBPase-2 (HGMW-approved symbol PFKFB1) to the X chromosome; however, precise localization remained ambiguous, with the gene variously placed
S Ros et al.
Oncogene, 36(23), 3287-3299 (2017-01-17)
The bifunctional enzyme 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-4 (PFKFB4) controls metabolic flux through allosteric regulation of glycolysis. Here we show that p53 regulates the expression of PFKFB4 and that p53-deficient cancer cells are highly dependent on the function of this enzyme. We found that
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